Facile entries for regioselective synthesis of [1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones from 2-thiouracil

被引：11
作者：
Shawali, A. S. [1 ]
Abbas, I. M.
Mahran, A. M.
机构：
[1] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt
[2] Natl Res Ctr, Giza, Egypt
来源：
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY | 2004年 / 1卷 / 01期
关键词：
heterocycles; hydrazones; rearrangement; synthetic methods; 1,2,4-triazolo-pyrimidine;
D O I：
10.1007/BF03245768
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Three new alternative synthetic strategies based on reactions of hydrazonoyl halides 3 with 2-methylthiouracil 2 and treatment of either 2-pyrimidinyl thiohydrazonates 8 or the diazonium coupling products of active (pyrimidin-2-ylthio)methylene compounds 12 with sodium ethoxide in ethanol are described for the title compounds. The mechanisms and regiochemistry of the studied reactions are discussed.
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页码：33 / 39
页数：7
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