Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies

被引：28

作者：

Praestegaard, Camilla ^{[1
]}

Jensen, Allan ^{[1
]}

Jensen, Signe M. ^{[2
]}

Nielsen, Thor S. S. ^{[1
]}

Webb, Penelope M. ^{[3
]}

Nagle, Christina M. ^{[3
]}

DeFazio, Anna ^{[4
,5
]}

Hogdall, Estrid ^{[1
,6
]}

Rossing, Mary Anne ^{[7
,8
]}

Doherty, Jennifer A. ^{[9
]}

Wicklund, Kristine G. ^{[7
]}

Goodman, Marc T. ^{[10
,11
]}

Modugno, Francesmary ^{[12
,13
,14
,15
]}

Moysich, Kirsten ^{[16
]}

Ness, Roberta B. ^{[17
]}

Edwards, Robert ^{[12
,14
,15
]}

Matsuo, Keitaro ^{[18
]}

Hosono, Satoyo ^{[19
]}

Goode, Ellen L. ^{[20
]}

Winham, Stacey J. ^{[21
]}

Fridley, Brooke L. ^{[22
]}

Cramer, Daniel W. ^{[23
,24
]}

Terry, Kathryn L. ^{[23
,24
]}

Schildkraut, Joellen M. ^{[25
]}

Berchuck, Andrew ^{[26
]}

Bandera, Elisa, V ^{[27
,28
]}

Paddock, Lisa E. ^{[29
,30
]}

Massuger, Leon F. ^{[31
]}

Wentzensen, Nicolas ^{[32
]}

Pharoah, Paul ^{[33
]}

Song, Honglin ^{[33
]}

Whittemore, Alice ^{[34
,35
,36
]}

McGuire, Valerie ^{[34
]}

Sieh, Weiva ^{[37
,38
]}

Rothstein, Joseph ^{[37
,38
]}

Anton-Culver, Hoda ^{[39
]}

Ziogas, Argyrios ^{[40
]}

Menon, Usha ^{[41
]}

Gayther, Simon A. ^{[42
,43
]}

Ramus, Susan J. ^{[44
,45
]}

Gentry-Maharaj, Alexandra ^{[41
]}

Wu, Anna H. ^{[46
]}

Pearce, Celeste L. ^{[46
,47
]}

Pike, Malcolm ^{[46
,48
]}

Lee, Alice W. ^{[49
]}

Sutphen, Rebecca ^{[50
]}

Chang-Claude, Jenny ^{[51
,52
]}

Risch, Harvey A. ^{[53
]}

Kjaer, Susanne K. ^{[1
,54
]}

机构：

[1] Danish Canc Soc, Res Ctr, Virus Lifestyle & Genes, Strandboulevarden 49, DK-2100 Copenhagen, Denmark

[2] Danish Canc Soc, Res Ctr, Stat Bioinformat & Registry, Copenhagen, Denmark

[3] QIMR Berghofer Med Res Inst, Populat Hlth Dept, Herston, Qld, Australia

[4] Univ Sydney, Ctr Canc Res, Westmead Millenium Inst Med Res, Westmead, NSW, Australia

[5] Westmead Hosp, Dept Gynecol Oncol, Westmead, NSW, Australia

[6] Univ Copenhagen, Herlev Hosp, Dept Pathol, Mol Unit, Copenhagen, Denmark

[7] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Epidemiol, 1124 Columbia St, Seattle, WA 98104 USA

[8] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[9] Dartmouth Coll, Dept Epidemiol, Geisel Sch Med, Hanover, NH 03755 USA

[10] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Canc Prevent & Control, Los Angeles, CA USA

[11] Cedars Sinai Med Ctr, Dept Biomed Sci, Community & Populat Hlth Res Inst, Los Angeles, CA 90048 USA

[12] Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, Div Gynecol Oncol, Pittsburgh, PA USA

[13] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA

[14] Magee Womens Res Inst, Ovarian Canc Ctr Excellence, Womens Canc Res Program, Pittsburgh, PA USA

[15] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA

[16] Roswell Pk Canc Inst, Dept Canc Prevent & Control, Buffalo, NY 14263 USA

[17] Univ Texas Houston, Sch Publ Hlth, Houston, TX USA

[18] Aichi Canc Ctr, Res Inst, Div Mol Med, Nagoya, Aichi, Japan

[19] Aichi Canc Ctr, Res Inst, Div Epidemiol & Prevent, Nagoya, Aichi, Japan

[20] Mayo Clin, Dept Hlth Sci Res, Div Epidemiol, Rochester, MN USA

[21] Mayo Clin, Div Biomed Stat & Informat, Dept Hlth Sci Res, Rochester, MN USA

[22] Univ Kansas, Med Ctr, Kansas City, KS 66103 USA

[23] Brigham & Womens Hosp, Obstet & Gynecol Epidemiol Ctr, 75 Francis St, Boston, MA 02115 USA

[24] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[25] Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA

[26] Duke Univ, Med Ctr, Dept Obstet & Gynecol, Durham, NC 27710 USA

[27] Rutgers Canc Inst New Jersey, Canc Prevent & Control Program, New Brunswick, NJ USA

[28] Rutgers Sch Publ Hlth, Piscataway, NJ USA

[29] New Jersey Dept Hlth & Senior Serv, Trenton, NJ USA

[30] Univ Med & Dent New Jersey, Sch Publ Hlth, Piscataway, NJ 08854 USA

[31] Radboud Univ Nijmegen, Med Ctr, Radboud Inst Mol Life Sci, Dept Gynaecol, Nijmegen, Netherlands

[32] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[33] Univ Cambridge, Dept Oncol, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Cambridge, England

[34] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Stanford, CA USA

[35] Stanford Sch Med, Dept Hlth Res & Policy, Stanford, CA USA

[36] Stanford Sch Med, Dept Biomed Data Sci, Stanford, CA USA

[37] Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, New York, NY 10029 USA

[38] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA

[39] Univ Calif Irvine, Sch Med, Ctr Canc Genet Res & Prevent, Dept Epidemiol, Irvine, CA 92717 USA

[40] Univ Calif Irvine, Dept Epidemiol, Irvine, CA USA

[41] UCL, Inst Womens Hlth, Womens Canc, London, England

[42] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Ctr Canc Prevent & Translat Genom, Los Angeles, CA 90048 USA

[43] Cedars Sinai Med Ctr, Dept Biomed Sci, Los Angeles, CA 90048 USA

[44] Univ New South Wales, Sch Womens & Childrens Hlth, Sydney, NSW, Australia

[45] Garvan Inst Med Res, Kinghorn Canc Ctr, Darlinghurst, NSW, Australia

[46] Univ Southern Calif, Keck Sch Med, Norris Comprehens Canc Ctr, Dept Prevent Med, Los Angeles, CA USA

[47] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA

[48] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, 1275 York Ave, New York, NY 10021 USA

[49] Calif State Univ, Dept Hlth Sci, Fullerton, CA USA

[50] Univ S Florida, Coll Med, Epidemiol Ctr, Tampa, FL USA

来源：

INTERNATIONAL JOURNAL OF CANCER | 2017年 / 140卷 / 11期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

cigarette smoking; ovarian cancer; survival; pooled analysis; PROGNOSTIC-FACTORS; RISK; MORTALITY; OBESITY; INFLAMMATION; METAANALYSIS; STATISTICS; OVERWEIGHT; IMPACT; COHORT;

D O I：

10.1002/ijc.30600

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cigarette smoking is associated with an increased risk of developing mucinous ovarian tumors but whether it is associated with ovarian cancer survival overall or for the different histotypes is unestablished. Furthermore, it is unknown whether the association between cigarette smoking and survival differs according to strata of ovarian cancer stage at diagnosis. In a large pooled analysis, we evaluated the association between various measures of cigarette smoking and survival among women with epithelial ovarian cancer. We obtained data from 19 case-control studies in the Ovarian Cancer Association Consortium (OCAC), including 9,114 women diagnosed with ovarian cancer. Cox regression models were used to estimate adjusted study-specific hazard ratios (HRs), which were combined into pooled hazard ratios (pHR) with corresponding 95% confidence intervals (CIs) under random effects models. Overall, 5,149 (57%) women died during a median follow-up period of 7.0 years. Among women diagnosed with ovarian cancer, both current (pHR=1.17, 95% CI: 1.08-1.28) and former smokers (pHR=1.10, 95% CI: 1.02-1.18) had worse survival compared with never smoking women. In histotype-stratified analyses, associations were observed for mucinous (current smoking: pHR=1.91, 95% CI: 1.01-3.65) and serous histotypes (current smoking: pHR=1.11, 95% CI: 1.00-1.23; former smoking: pHR=1.12, 95% CI: 1.04-1.20). Further, our results suggested that current smoking has a greater impact on survival among women with localized than disseminated disease. The identification of cigarette smoking as a modifiable factor associated with survival has potential clinical importance as a focus area to improve ovarian cancer prognosis. What's new? The number of female smokers is declining worldwide but an estimated 180 million women still smoke daily worldwide. Here the authors examined the association between cigarette smoking and ovarian cancer survival. Current and former smoking shortened survival compared to women who had never smoked, especially in those afflicted with mucinous and serous tumors and with localized disease. The study identifies cigarette smoking as a modifiable factor associated with ovarian cancer survival.

引用

页码：2422 / 2435

页数：14

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