Matrix metalloproteinase 12 silencing: A therapeutic approach to treat pathological lung tissue remodeling?

被引：38

作者：

Garbacki, Nancy ^{[1
]}

Di Valentin, Emmanuel ^{[2
]}

Piette, Jacques ^{[2
]}

Cataldo, Didier ^{[3
]}

Crahay, Celine ^{[3
]}

Colige, Alain ^{[1
]}

机构：

[1] Univ Liege, GIGA Res, Lab Connect Tissue Biol, B-4000 Liege, Belgium

[2] Univ Liege, GIGA Res, Lab Fundamental Virol & Immunol, B-4000 Liege, Belgium

[3] Univ Liege, GIGA Res, Lab Biol Tumours & Dev, B-4000 Liege, Belgium

来源：

PULMONARY PHARMACOLOGY & THERAPEUTICS | 2009年 / 22卷 / 04期

关键词：

siRNA delivery; RNA interference; MMP-12; Asthma; COPD; Therapy; OBSTRUCTIVE PULMONARY-DISEASE; MACROPHAGE METALLOELASTASE MMP-12; SMALL INTERFERING RNA; INDUCED AIRWAY INFLAMMATION; COLONY-STIMULATING FACTOR; CIGARETTE-SMOKE; GENE-EXPRESSION; EXTRACELLULAR-MATRIX; PERIPHERAL-BLOOD; MANNOSE RECEPTOR;

D O I：

10.1016/j.pupt.2009.03.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Among the large matrix metalloproteinases (MMPs) family, MMP-12, also referred to as macrophage elastase, plays a significant role in chronic pulmonary pathologies characterized by an intense tissue remodeling such as asthma and COPD. This review will summarize knowledge about MMP-12 structure, functions and mechanisms of activation and regulation, including potential MMP-12 modulation by microRNA. As MMP-12 is involved in many tissue remodeling diseases, efforts have been made to develop specific synthetic inhibitors. However, at this time, very few chemical inhibitors have proved to be efficient and specific to a particular MMP. The relevance of silencing MMP-12 by RNA interference is highlighted. The specificity of this approach using siRNA or shRNA and the strategies to deliver these molecules in the lung are discussed. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：267 / 278

页数：12

共 151 条

[1] Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metal loproteinase-12 in non-small cell lung cancer [J].

Acuff, Heath B. ;

Sinnamon, Mark ;

Fingleton, Barbara ;

Boone, Braden ;

Levy, Shawn E. ;

Chen, Xiwu ;

Pozzi, Ambra ;

Carbone, David P. ;

Schwartz, Donald R. ;

Moin, Kamiar ;

Sloane, Bonnie F. ;

Matrisian, Lynn M. .

CANCER RESEARCH, 2006, 66 (16) :7968-7975

[2] Gene silencing through RNA interference (RNAi) in vivo: Strategies based on the direct application of siRNAs [J].

Aigner, A .

JOURNAL OF BIOTECHNOLOGY, 2006, 124 (01) :12-25

[3] Cytokines induce airway smooth muscle cell hyperresponsiveness to contractile agonists [J].

Amrani, Y ;

Panettieri, RA .

THORAX, 1998, 53 (08) :713-716

[4] Synthesis and matrix metalloproteinase (MMP)-12 inhibitory activity of ageladine A and its analogs [J].

Ando, Naoki ;

Terashima, Shiro .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (16) :4495-4499

[5] Induction of macrophage elastase (MMP-12) gene expression by statins [J].

Arikan, MC ;

Shapiro, SD ;

Mariani, TJ .

JOURNAL OF CELLULAR PHYSIOLOGY, 2005, 204 (01) :139-145

[6] Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling [J].

Ashworth, JL ;

Murphy, G ;

Rock, MJ ;

Sherratt, MJ ;

Shapiro, SD ;

Shuttleworth, CA ;

Kielty, CM .

BIOCHEMICAL JOURNAL, 1999, 340 :171-181

[7] Targeted delivery of nanoparticles for the treatment of lung diseases [J].

Azarmi, Shirzad ;

Roa, Wilson H. ;

Loebenberg, Raimar .

ADVANCED DRUG DELIVERY REVIEWS, 2008, 60 (08) :863-875

[8] Patterns of airway inflammation and MMP-12 expression in smokers and ex-smokers with COPD [J].

Babusyte, Agne ;

Stravinskaite, Kristina ;

Jeroch, Jolanta ;

Lotvall, Jan ;

Sakalauskas, Raimundas ;

Sitkauskiene, Brigita .

RESPIRATORY RESEARCH, 2007, 8

[9] Chronic obstructive pulmonary disease: molecular and cellular mechanisms [J].

Barnes, PJ ;

Shapiro, SD ;

Pauwels, RA .

EUROPEAN RESPIRATORY JOURNAL, 2003, 22 (04) :672-688

[10]

Beasley R., 2002, Clinical and Experimental Allergy Reviews, V2, P109, DOI 10.1046/j.1472-9725.2.s4.1.x

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