Hyperinsulinaemia, a key factor of the metabolic syndrome in postmenopausal women

被引:51
作者
Gaspard, Ulysse [1 ]
机构
[1] Univ Liege, Sart Tilman Univ Hosp, Dept Obstet & Gynaecol, B-4000 Liege 1, Belgium
关键词
Postmenopause; Metabolic syndrome; Cardiovascular risk in women; Diabetes in women; Insulin resistance; Obesity; Adipocytokines; HORMONE-REPLACEMENT THERAPY; BODY-FAT DISTRIBUTION; INSULIN SENSITIVITY; ADIPOSE-TISSUE; CONSENSUS STATEMENT; CARDIOVASCULAR RISK; GLUCOSE-TOLERANCE; MENOPAUSE; RESISTANCE; ADIPONECTIN;
D O I
10.1016/j.maturitas.2008.11.026
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
The metabolic syndrome (MetS) is a complex disorder combining obesity, hypertension, atherogenic dyslipidaemia and insulin resistance, a clustering of factors which markedly enhance the risk of developing cardiovascular disease (CVD) and type 2 diabetes. Main features of the MetS, which are found in many postmenopausal women, are increasing prevalence of insulin resistance and obesity (particularly visceral adiposity). Accordingly, a majority of postmenopausal women comply with criteria defining the MetS, and CVD is the first cause of morbidity/mortality in women, occurring even more frequently than in men. Moreover, obesity-related type 2 diabetes approaches pandemic proportions. Simultaneous occurrence of insulin resistance and obesity are most detrimental for metabolic health, and are also associated with increased oxidative stress, inflammatory and prothrombotic processes as well as with postmenopausal alterations in adipocytokine production. Hormone replacement therapy, provided the selected progestin does not antagonize estrogen action, may improve fat mass and distribution, dyslipidaemia and insulin sensitivity in postmenopausal women. (c) 2009 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:362 / 365
页数:4
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