Circular RNAs (circRNAs) in cancer

被引：229

作者：

Zhou, Ruoyu ^{[1
,2
]}

Wu, Yuwei ^{[1
,2
]}

Wang, Wenxi ^{[1
]}

Su, Wenjia ^{[1
]}

Liu, Yicong ^{[1
]}

Wang, Yumin ^{[1
,2
]}

Fan, Chunmei ^{[2
]}

Li, Xiaoling ^{[1
,2
,3
]}

Li, Guiyuan ^{[1
,2
,3
]}

Li, Yong ^{[2
,4
]}

Xiong, Wei ^{[1
,2
,3
]}

Zeng, Zhaoyang ^{[1
,2
,3
]}

机构：

[1] Cent S Univ, Xiangya Hosp, Key Lab Carcinogenesis, Chinese Minist Hlth, Changsha, Hunan, Peoples R China

[2] Cent S Univ, Key Lab Carcinogenesis & Canc Invas, Chinese Minist Educ, Canc Res Inst, Changsha, Hunan, Peoples R China

[3] Cent S Univ, Xiangya Hosp 3, Hunan Key Lab Nonresolving Inflammat & Canc, Dis Genome Res Ctr, Changsha, Hunan, Peoples R China

[4] Cleveland Clin, Dept Canc Biol, Lerner Res Inst, Cleveland, OH 44106 USA

来源：

CANCER LETTERS | 2018年 / 425卷

基金：

中国国家自然科学基金;

关键词：

circRNAs; Cancer; Regulation; Sponge; EMERGING ROLES; MESENCHYMAL TRANSITION; COLORECTAL-CANCER; BREAST-CANCER; CELL-GROWTH; EXPRESSION; BIOMARKER; IDENTIFICATION; TRANSLATION; PROGRESSION;

D O I：

10.1016/j.canlet.2018.03.035

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Circular RNAs (circRNAs) are a class of non-coding RNAs that do not have 5' end caps or 3' end poly (A) tails. There are more than one hundred thousand genes that encode circRNAs. Clinical data show that there are differences in the expression of circRNAs in a variety of diseases, including cancer, suggesting that circRNA has a regulatory effect on some diseases. Further studies reveal that circRNA can be used as an endogenous competitive RNA, thereby regulating the proliferation, invasion or other physiological activities of tumor cells. In addition, some circRNAs located in the nucleus can regulate the transcription of the parental gene by binding to RNA polymerase II, circRNA can also combine with proteins to influence the cell cycle. Furthermore, recent studies have shown that circRNA can encode proteins, similarly to mRNA. circRNAs are found extensively in human cells and have tissue specificity. They have the potential to be used in clinical applications as tumor markers and therapeutic targets. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：134 / 142

页数：9

共 97 条

[1] Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1 [J].

Abdelmohsen, Kotb ;

Panda, Amaresh C. ;

Munk, Rachel ;

Grammatikakis, Ioannis ;

Dudekula, Dawood B. ;

De, Supriyo ;

Kim, Jiyoung ;

Noh, Ji Heon ;

Kim, Kyoung Mi ;

Martindale, Jennifer L. ;

Gorospe, Myriam .

RNA BIOLOGY, 2017, 14 (03) :361-369

[2] Rolling Circle Translation of Circular RNA in Living Human Cells [J].

Abe, Naoko ;

Matsumoto, Ken ;

Nishihara, Mizuki ;

Nakano, Yukiko ;

Shibata, Aya ;

Maruyama, Hideto ;

Shuto, Satoshi ;

Matsuda, Akira ;

Yoshida, Minoru ;

Ito, Yoshihiro ;

Abe, Hiroshi .

SCIENTIFIC REPORTS, 2015, 5

[3] Emerging Roles of Disordered Sequences in RNA-Binding Proteins [J].

Calabretta, Sara ;

Richard, Stephane .

TRENDS IN BIOCHEMICAL SCIENCES, 2015, 40 (11) :662-672

[4] Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer [J].

Chen, Jie ;

Li, Yan ;

Zheng, Qiupeng ;

Bao, Chunyang ;

He, Jian ;

Chen, Bin ;

Lyu, Dongbin ;

Zheng, Biqiang ;

Xu, Yu ;

Long, Ziwen ;

Zhou, Ye ;

Zhu, Huiyan ;

Wang, Yanong ;

He, Xianghuo ;

Shi, Yingqiang ;

Huang, Shenglin .

CANCER LETTERS, 2017, 388 :208-219

[5] RETRACTED: circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family (Retracted article. See vol. 38, pg. 5750, 2019) [J].

Chen, L. ;

Zhang, S. ;

Wu, J. ;

Cui, J. ;

Zhong, L. ;

Zeng, L. ;

Ge, S. .

ONCOGENE, 2017, 36 (32) :4551-4561

[6] Circular RNAs in Eukaryotic Cells [J].

Chen, Liang ;

Huang, Chuan ;

Wang, Xiaolin ;

Shan, Ge .

CURRENT GENOMICS, 2015, 16 (05) :312-318

[7] Regulation of circRNA biogenesis [J].

Chen, Ling-Ling ;

Yang, Li .

RNA BIOLOGY, 2015, 12 (04) :381-388

[8] Using circular RNA hsa_circ_0000190 as a new biomarker in the diagnosis of gastric cancer [J].

Chen, Shijun ;

Li, Tianwen ;

Zhao, Qianfu ;

Xiao, Bingxiu ;

Guo, Junming .

CLINICA CHIMICA ACTA, 2017, 466 :167-171

[9] circRNADb: A comprehensive database for human circular RNAs with protein-coding annotations [J].

Chen, Xiaoping ;

Han, Ping ;

Zhou, Tao ;

Guo, Xuejiang ;

Song, Xiaofeng ;

Li, Yan .

SCIENTIFIC REPORTS, 2016, 6

[10] MISSPLICING YIELDS CIRCULAR RNA MOLECULES [J].

COCQUERELLE, C ;

MASCREZ, B ;

HETUIN, D ;

BAILLEUL, B .

FASEB JOURNAL, 1993, 7 (01) :155-160

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