IL-17F: Regulation, signaling and function in inflammation

被引：139

作者：

Chang, Seon Hee ^{[1
]}

Dong, Chen ^{[1
]}

机构：

[1] Univ Texas Houston, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

来源：

CYTOKINE | 2009年 / 46卷 / 01期

关键词：

IL-17; IL-17F; Inflammation; Signaling; COLONY-STIMULATING FACTOR; CELL-MEDIATED COLITIS; ACTIVE CROHNS-DISEASE; CUTTING EDGE; INTERLEUKIN-17; RECEPTOR; HOST-DEFENSE; TH17; CELLS; T-CELLS; CYTOKINE; EXPRESSION;

D O I：

10.1016/j.cyto.2008.12.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The IL-17 cytokine family is composed of six members. IL-17F, discovered in 2001, recently has drawn increasing attention due to its greatest similarity to IL-17, a widely recognized inflammatory cytokine. The genes encoding IL-17 and IL-17F are localized in the same chromosomal region and are co-expressed by CD4+ and gamma delta T cells. IL-17F can be secreted as homodimers or heterodimers with IL-17. Similar to IL-17, IL-17F utilizes IL-17RA and IL-17RC as its receptor and employs Act1 and TRAF6 as its signal transducers to induce the expression of pro-inflammatory cytokines and chemokines in many different cell types. However, mice lacking either IL-17 or IL-17F exhibit distinct defects in experimental models of asthma and colitis. These results have laid the basis to understand the role of IL-17F in the pathogenesis of human diseases. Published by Elsevier Ltd.

引用

页码：7 / 11

页数：5

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