IL-17F: Regulation, signaling and function in inflammation

被引:140
作者
Chang, Seon Hee [1 ]
Dong, Chen [1 ]
机构
[1] Univ Texas Houston, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA
关键词
IL-17; IL-17F; Inflammation; Signaling; COLONY-STIMULATING FACTOR; CELL-MEDIATED COLITIS; ACTIVE CROHNS-DISEASE; CUTTING EDGE; INTERLEUKIN-17; RECEPTOR; HOST-DEFENSE; TH17; CELLS; T-CELLS; CYTOKINE; EXPRESSION;
D O I
10.1016/j.cyto.2008.12.024
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The IL-17 cytokine family is composed of six members. IL-17F, discovered in 2001, recently has drawn increasing attention due to its greatest similarity to IL-17, a widely recognized inflammatory cytokine. The genes encoding IL-17 and IL-17F are localized in the same chromosomal region and are co-expressed by CD4+ and gamma delta T cells. IL-17F can be secreted as homodimers or heterodimers with IL-17. Similar to IL-17, IL-17F utilizes IL-17RA and IL-17RC as its receptor and employs Act1 and TRAF6 as its signal transducers to induce the expression of pro-inflammatory cytokines and chemokines in many different cell types. However, mice lacking either IL-17 or IL-17F exhibit distinct defects in experimental models of asthma and colitis. These results have laid the basis to understand the role of IL-17F in the pathogenesis of human diseases. Published by Elsevier Ltd.
引用
收藏
页码:7 / 11
页数:5
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