Understanding the tolerance of the industrial yeast Saccharomyces cerevisiae against a major class of toxic aldehyde compounds

被引:37
作者
Liu, ZongLin Lewis [1 ]
机构
[1] ARS, USDA, Natl Ctr Agr Utilizat Res, Bioenergy Res Unit, 1815 N Univ St, Peoria, IL 61604 USA
基金
美国食品与农业研究所;
关键词
Gene expression; Gene regulatory networks; Genomic adaptation; In situ detoxification; Lignocellulose conversion; Reprogrammed pathways; Stress tolerance; PENTOSE-PHOSPHATE PATHWAY; IN-SITU DETOXIFICATION; ETHANOLOGENIC YEAST; STRESS-TOLERANCE; FURFURYL ALCOHOL; ACETIC-ACID; FERMENTATION INHIBITORS; SIGNALING PATHWAYS; XYLOSE UTILIZATION; ADAPTIVE RESPONSE;
D O I
10.1007/s00253-018-8993-6
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Development of the next-generation biocatalyst is vital for fermentation-based industrial applications and a sustainable bio-based economy. Overcoming the major class of toxic compounds associated with lignocellulose-to-biofuels conversion is one of the significant challenges for new strain development. A significant number of investigations have been made to understand mechanisms of the tolerance for industrial yeast. It is humbling to learn how complicated the cell's response to the toxic chemicals is and how little we have known about yeast tolerance in the universe of the living cell. This study updates our current knowledge on the tolerance of industrial yeast against aldehyde inhibitory compounds at cellular, molecular and the genomic levels. It is comprehensive yet specific based on reproducible evidence and cross confirmed findings from different investigations using varied experimental approaches. This research approaches a rational foundation toward a more comprehensive understanding on the yeast tolerance. Discussions and perspectives are also proposed for continued exploring the puzzle of the yeast tolerance to aid the next-generation biocatalyst development.
引用
收藏
页码:5369 / 5390
页数:22
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