Metallamacrocycle formation through dimerization of metal bioconjugates derived from amino acids and peptides

被引：5

作者：

Alvarez, Celedonio M. ^{[1
]}

Garcia-Rodriguez, Raul ^{[1
]}

Miguel, Daniel ^{[1
]}

机构：

[1] Univ Valladolid, Fac Ciencias, GIR MIOMET IU CINQUIMA Quim Inorgan, E-47005 Valladolid, Spain

来源：

DALTON TRANSACTIONS | 2016年 / 45卷 / 03期

关键词：

DERIVATIZED DIIMINE LIGANDS; THIOLATE NUCLEOPHILICITY; CARBONYL-COMPLEXES; TUNGSTEN COMPOUNDS; CRYSTAL-STRUCTURE; HYDROGEN-BOND; MOLYBDENUM; RHENIUM; DESIGN; EPIMERIZATION;

D O I：

10.1039/c5dt01256b

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Metallamacrocycles of 12, 16, and 22 members are obtained by deprotonation of the carboxylic group of the side chain of iminopyridine complexes derived from the amino acid beta-alanine, and the peptides Gly-Gly and Gly-Gly-Gly. Instead of the expected intramolecular attack to give tridentate (N, N, O) ligands, the deprotonated carboxylate attacks in an inter-molecular manner to give dimers in which the ligand acts as a bridge bonded in a kappa(2)(N, N') chelating fashion to one metal and as kappa(O) to the other metal. The formation of the dimers is supported by NMR spectroscopy, mass spectrometry and X-ray crystallography.

引用

页码：963 / 972

页数：10

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