Exceptional Evolutionary Divergence of Human Muscle and Brain Metabolomes Parallels Human Cognitive and Physical Uniqueness

被引：69

作者：

Bozek, Katarzyna ^{[1
,2
]}

Wei, Yuning ^{[1
,3
]}

Yan, Zheng ^{[1
]}

Liu, Xiling ^{[1
]}

Xiong, Jieyi ^{[1
,3
]}

Sugimoto, Masahiro ^{[4
]}

Tomita, Masaru ^{[4
]}

Paeaebo, Svante ^{[2
]}

Pieszek, Raik ^{[2
]}

Sherwood, Chet C. ^{[5
]}

Hof, Patrick R. ^{[6
,7
]}

Ely, John J. ^{[8
]}

Steinhauser, Dirk ^{[9
]}

Willmitzer, Lothar ^{[9
]}

Bangsbo, Jens ^{[10
]}

Hansson, Ola ^{[11
]}

Call, Josep ^{[2
]}

Giavalisco, Patrick ^{[9
]}

Khaitovich, Philipp ^{[1
,2
]}

机构：

[1] CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol, Shanghai, Peoples R China

[2] Max Planck Inst Evolutionary Anthropol, Leipzig, Germany

[3] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

[4] Keio Univ, Inst Adv Biosci, Tsuruoka, Yamagata, Japan

[5] George Washington Univ, Dept Anthropol, Washington, DC USA

[6] Icahn Sch Med Mt Sinai, Fishberg Dept Neurosci, New York, NY USA

[7] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA

[8] Holloman AFB, Alamogordo Primate Facil, Alamogordo, NM USA

[9] Max Planck Inst Mol Plant Physiol, Potsdam, Germany

[10] Univ Copenhagen, Dept Exercise & Sport Sci, Sect Human Physiol, Copenhagen, Denmark

[11] Lund Univ, Malmo Univ Hosp, Dept Clin Sci, Malmo, Sweden

来源：

PLOS BIOLOGY | 2014年 / 12卷 / 05期

基金：

中国国家自然科学基金; 美国国家科学基金会;

关键词：

CHIMPANZEE; MASS; METABOLITES;

D O I：

10.1371/journal.pbio.1001871

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabolite concentrations reflect the physiological states of tissues and cells. However, the role of metabolic changes in species evolution is currently unknown. Here, we present a study of metabolome evolution conducted in three brain regions and two non-neural tissues from humans, chimpanzees, macaque monkeys, and mice based on over 10,000 hydrophilic compounds. While chimpanzee, macaque, and mouse metabolomes diverge following the genetic distances among species, we detect remarkable acceleration of metabolome evolution in human prefrontal cortex and skeletal muscle affecting neural and energy metabolism pathways. These metabolic changes could not be attributed to environmental conditions and were confirmed against the expression of their corresponding enzymes. We further conducted muscle strength tests in humans, chimpanzees, and macaques. The results suggest that, while humans are characterized by superior cognition, their muscular performance might be markedly inferior to that of chimpanzees and macaque monkeys.

引用

页数：14

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