Vitexlactam A, a novel labdane diterpene lactam from the fruits of Vitex agnus-castus

被引：52
作者：
Li, SH
Zhang, HJ
Qiu, SX [1 ]
Niu, XM
Santarsiero, BD
Mesecar, AD
Fong, HHS
Farnsworth, NR
Sun, HD
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
[2] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA
[3] Herbstandard Inc, Chesterfield, MO 63017 USA
[4] Univ Illinois, Dept Med Chem & Pharmacognosy, Chicago, IL 60607 USA
[5] Univ Illinois, Ctr Pharmaceut Biotechnol, Chicago, IL 60607 USA
[6] Univ Illinois, UIC NIH Ctr Bot Dietary Supplements Res, Chicago, IL 60612 USA
来源：
TETRAHEDRON LETTERS | 2002年 / 43卷 / 29期
关键词：
Vitex agnus-castus; Verbenaceae; labdane diterpene; lactam; vitexlactam A; NMR; X-ray;
D O I：
10.1016/S0040-4039(02)00981-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel labdane diterpene alkaloid, vitexlactam A (1) was isolated as a prism from the n-hexane extract of the fruits of Vitex agnus-castus through normal and reverse phase column chromatography. Its structure was elucidated to be 6beta-acetoxy-9alpha-hydroxy-13(14)-labden-16,15-amide, based on chemical and spectral evidences including 1D and 2D NMR spectra. The structure was confirmed by X-ray crystallographic analysis. Compound 1 is the first naturally occurring labdane diterpenoid containing an alpha,beta-unsaturated gamma-lactam moiety. (C) 2002 Elsevier Science Ltd. All rights reserved.
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收藏
页码：5131 / 5134
页数：4
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