Vγ6+ γδ T cells are critical for protection against infection by Escherichia coli in mice

被引：0

作者：

Tun, Xin ^{[1
]}

Hatano, Shinya ^{[1
]}

Mine, Keiichiro ^{[1
]}

Noguchi, Naoto ^{[1
]}

Iwakura, Yoichiro ^{[2
]}

Sun, Xun ^{[3
]}

Yoshikai, Yasunobu ^{[1
]}

机构：

[1] Kyushu Univ, Med Inst Bioregulat, Div Host Def, Fukuoka 8128582, Japan

[2] Tokyo Univ Sci, Res Inst Biomed Sci, Ctr Anim Dis Models, Noda, Chiba, Japan

[3] China Med Univ, Dept Immunol, Shenyang, Peoples R China

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2021年 / 51卷 / 08期

关键词：

gamma delta T cells; V gamma delta; Escherichia coli; infection; neutrophils; EXPRESSION; FETAL;

D O I：

10.1002/eji.202049010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

gamma delta T cells producing IL-17A (gamma delta Th17 cells) are known to be involved in peritonitis induced by Escherichia coli infection in mice. In vivo treatment with V gamma 6-specific mAb (1C10-1F7) significantly hampered resolution of E. coli infection. Thus, V gamma 6(+)gamma delta Th17 cells mainly contributed to protection against E. coli infection.

引用

页码：2093 / 2096

页数：4

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