Severe asthma: Lessons from the Severe Asthma Research Program

被引:185
作者
Wenzel, Sally E.
Busse, William W.
机构
[1] Univ Pittsburgh, Med Ctr, Pittsburgh, PA 15213 USA
[2] Univ Wisconsin, Med Ctr, Madison, WI 53706 USA
关键词
asthma; allergy; phenotypes; corticosteroids;
D O I
10.1016/j.jaci.2006.10.025
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Severe asthma affects only a small percentage of the asthma population. However, these patients remain poorly understood and difficult to treat. Because the numbers are relatively small (10% or less of the asthma population), a network approach with shared protocols, samples, and data provides a unique opportunity to recruit the numbers of subjects necessary to perform adequately powered studies. The Severe Asthma Network (Severe Asthma Research Program) was established by the National Heart, Lung, and Blood Institute in 2001 to advance collectively the study of severe asthma to determine factors that differentiated these patients or subjects from those with milder asthma. Nearly 800 subjects have been recruited in less than 4 years to begin to address these differences. Future studies will specifically evaluate the role of inflammatory/oxidative processes, infection, genetics, and the distal lung in the pathogenesis of severe asthma.
引用
收藏
页码:14 / 21
页数:8
相关论文
共 43 条
[1]   The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma [J].
Abraham, B ;
Antó, JM ;
Barreiro, E ;
Bel, EHD ;
Bonsignore, G ;
Bousquet, J ;
Castellsague, J ;
Chanez, P ;
Cibella, F ;
Cuttitta, G ;
Dahlén, B ;
Dahlén, SE ;
Drews, N ;
Djukanovic, R ;
Fabbri, LM ;
Folkerts, G ;
Gaga, M ;
Gratziou, C ;
Guerrera, G ;
Holgate, ST ;
Howarth, PH ;
Johnston, SL ;
Kanniess, F ;
Kips, JC ;
Kerstjens, HAM ;
Kumlin, M ;
Magnussen, H ;
Nijkamp, FP ;
Papageorgiou, N ;
Papi, A ;
Postma, DS ;
Pauwels, RA ;
Rabe, KF ;
Richter, K ;
Roldaan, AC ;
Romagnoli, M ;
Roquet, A ;
Sanjuas, C ;
Siafakas, NM ;
Timens, W ;
Tzanakis, N ;
Vachier, I ;
Vignola, AM ;
Watson, L ;
Yourgioti, G .
EUROPEAN RESPIRATORY JOURNAL, 2003, 22 (03) :470-477
[2]   Airway wall thickness in patients with near fatal asthma and control groups:: assessment with high resolution computed tomographic scanning [J].
Awadh, N ;
Müller, NL ;
Park, CS ;
Abboud, RT ;
FitzGerald, JM .
THORAX, 1998, 53 (04) :248-253
[3]   Relationship of small airway chymase-positive mast cells and lung function in severe asthma [J].
Balzar, S ;
Chu, HW ;
Strand, M ;
Wenzel, S .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2005, 171 (05) :431-439
[4]   Difficult asthma [J].
Barnes, PJ ;
Woolcock, AJ .
EUROPEAN RESPIRATORY JOURNAL, 1998, 12 (05) :1209-1218
[5]   Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase [J].
Barnes, PJ ;
Ito, K ;
Adcock, IM .
LANCET, 2004, 363 (9410) :731-733
[6]   The costs of asthma [J].
Barnes, PJ ;
Jonsson, B ;
Klim, JB .
EUROPEAN RESPIRATORY JOURNAL, 1996, 9 (04) :636-642
[7]   EFFECT OF HIGH-DOSE INHALED FLUTICASONE PROPIONATE ON AIRWAY INFLAMMATION IN ASTHMA [J].
BOOTH, H ;
RICHMOND, I ;
WARD, C ;
GARDINER, PV ;
HARKAWAT, R ;
WALTERS, EH .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1995, 152 (01) :45-52
[8]  
Busse William W., 2000, Journal of Allergy and Clinical Immunology, V106, P1033
[9]   Asthma exacerbations after glucocorticoid withdrawal reflects T cell recruitment to the airway [J].
Castro, M ;
Bloch, SR ;
Jenkerson, MV ;
DeMartino, S ;
Hamilos, DL ;
Cochran, RB ;
E, XP ;
Zhang, LA ;
Wang, HC ;
Bradley, JP ;
Schechtman, KB ;
Holtzman, MJ .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2004, 169 (07) :842-849
[10]  
CHANEZ P, 2007, IN PRESS J ALLERGY C