Mean Platelet Volume/Platelet Count Ratio and Culprit Plaque Morphologies: An Optical Coherence Tomography Study in Patients with ST Segment Elevation Myocardial Infarction

被引:4
|
作者
Song, Li [1 ]
Chen, Run-Zhen [1 ]
Zhao, Xiao-Xiao [1 ]
Sheng, Zhao-Xue [1 ]
Zhou, Peng [1 ]
Liu, Chen [1 ]
Li, Jian-Nan [1 ]
Zhou, Jin-Ying [1 ]
Wang, Ying [1 ]
Zhao, Han-Jun [1 ]
Yan, Hong-Bing [1 ,2 ]
机构
[1] Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Coronary Heart Dis Ctr, 167 Beilishi Rd, Beijing 100037, Peoples R China
[2] Chinese Acad Med Sci, Fuwai Hosp, Dept Cardiol, 12 Langshan Rd, Shenzhen 518000, Peoples R China
基金
中国国家自然科学基金;
关键词
mean platelet volume; platelet count ratio; Plaque rupture; ST segment elevation myocardial infarction; ACUTE CORONARY SYNDROMES; LONG-TERM MORTALITY; ATHEROSCLEROTIC PLAQUE; CALCIFIED NODULE; EROSION; VOLUME; MANAGEMENT; DIAGNOSIS; OUTCOMES; RUPTURE;
D O I
10.1007/s12265-021-10113-z
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This study aimed to investigate the predictive value of mean platelet volume/platelet count ratio (MPR) for coronary plaque features in patients with ST segment elevation myocardial infarction (STEMI). A total of 275 STEMI patients undergoing preintervention optical coherence tomography examination were included, with 142 categorized as plaque rupture (PR) and 133 as plaque erosion (PE). Multivariable logistic regression showed higher MPR was an independent predictor of PR (tertile 3 vs tertile 1, odds ratio: 6.257, 95% confidence interval: 1.586-24.686, P = 0.009). MPR showed better diagnostic performance than other platelet indices. The optimal MPR threshold for diagnosing PR was 0.0473 (sensitivity: 0.721, specificity: 0.647). When added to models of established risk factors, MPR significantly improved the predictive accuracy of PR (area under the curve: 0.767 vs 0.722, P-difference = 0.004). In conclusion, for STEMI patients, MPR was an independent predictor of PR and improved diagnostic performance for PR.
引用
收藏
页码:1093 / 1103
页数:11
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