Glucose metabolism in the idiopathic blepharoptosis: Utility of the Oral Glucose Tolerance Test (OGTT) and of the Insulin Resistance Index

被引:14
作者
Bosco, Domenico [1 ]
Costa, Raffaele [2 ]
Plastino, Massimiliano [1 ]
Branca, Damiano [10 ]
Cotronei, Piero [3 ]
Sperli, Teresa [3 ]
Santacroce, Nicola [4 ]
Siniscalchi, Antonio [5 ]
Consoli, Domenico [6 ]
Ceccotti, Claudio [7 ]
Mungari, Pasquale [8 ]
Fava, Antonietta [9 ]
机构
[1] S Giovanni di Dio Hosp, Dept Neurosci, I-88900 Crotone, Italy
[2] S Giovanni di Dio Hosp, Dept Med, I-88900 Crotone, Italy
[3] S Giovanni di Dio Hosp, Dept Geriatr, I-88900 Crotone, Italy
[4] Pugliese Ciaccio Hosp, Dept Ophthalmol, I-88100 Catanzaro, Italy
[5] Annunziata Hosp, Dept Neurosci, Cosenza, Italy
[6] G Jazzolino Hosp, Dept Neurosci, I-89900 Vibo Valentia, Italy
[7] Pugliese Ciaccio Hosp, Dept Neurosurg, I-88100 Catanzaro, Italy
[8] S Giovanni di Dio Hosp, Dept Emergency Med, I-88900 Crotone, Italy
[9] Magna Graecia Univ Catanzaro, Dept Clin & Expt Med, I-88100 Catanzaro, Italy
[10] Hosp Reggio Calabria, Dept Neurol, I-89100 Reggio Di Calabria, Italy
关键词
Idiopathic blepharoptosis; Neuropathy and diabetes mellitus; Impairment glucose tolerance; Insulin resistance; OCULAR PALSIES; COMPLICATIONS; NEUROPATHY; RISK;
D O I
10.1016/j.jns.2009.03.017
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Diabetes mellitus (DM), neuromuscolar, hereditary or immunological disorders are the most common identified causes of blepharoptosis. However, in about 15-25% they remained uncertain. Objective: To determined the role of glucose metabolism abnormality in idiopathic blepharoptosis. Methods: We identified 162 patients with unilateral idiopathic blepharoptosis and 128 control subjects. In all we evaluated a glucose and insulin levels at fasting and after 2 h-OGTT. In addition we determined insulin resistance (IR), by HOMA-index. Results: Following a 2 h-OGTT the prevalence of undiagnosed glucose metabolism abnormality was significantly higher in blepharoptosis patients vs. control group (P < .001). The IR was documented in 129 patients (78%), of whom 55 (34%) had Impaired Glucose Tolerance (IGT), 36 (22%) newly diagnosed DM (NDDM) and 38 (30%) only IR. The Body Mass Index, blood pressure, serum lipids, triglycerides and smoking were not associated with an increased risk of developing ptosis. Conversely, waist circumference were significantly increased in blepharoptosis patients (P = .003). Conclusions: In this study we focused on emerging evidence that prediabetic status may represent a risk factor for developing blepharoptosis. We propose that 2 h-OGTT and mainly HOMA-index should be determined as a rule in all patients with idiopathic blepharoptosis. (C) 2009 Published by Elsevier B. V.
引用
收藏
页码:24 / 28
页数:5
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