Synthesis of the Tricyclic Caged Core of Palhinine Alkaloids Based on a Non-Diels-Alder-Type Strategy

被引：7

作者：

Lu, Shi-Chao

Liang, Yu-Yan

Li, Liang ^{[2
,3
]}

Wang, Xiao-Lei

Zhang, Shi-Peng

Gong, Ya-Ling

Xu, Shu ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, 2A NanWei Rd, Beijing 100050, Peoples R China

[2] Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Haihe Educ Pk 38,Tongyan Rd, Tianjin 300350, Peoples R China

[3] Nankai Univ, Tianjin Key Lab Mol Drug Res, Haihe Educ Pk 38,Tongyan Rd, Tianjin 300350, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 14期

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

LYCOPODIUM ALKALOIDS; RING-SYSTEM; CONSTRUCTION;

D O I：

10.1021/acs.orglett.9b01898

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise synthesis of the tricyclo[4.3.1.0(3,7)]decane caged core of palhinine alkaloids was developed with SmI2-mediated cyclization and light-initiated radical addition-fragmentation as key steps. Compared with the reported racemic routes which are all based on Diels-Alder-type key reactions, our strategy would be more readily accessible to the asymmetric total syntheses of the palhinine alkaloids.

引用

页码：5567 / 5569

页数：3

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