Stem Cells: An Overview of the Current Status of Therapies for Central and Peripheral Nervous System Diseases

被引：41
作者：
Orlacchio, A. [1 ,2 ,3 ]
Bernardi, G. [1 ,2 ]
Orlacchio, A. [1 ,2 ,3 ]
Martino, S. [3 ]
机构：
[1] Ist Ricovero & Cura Carattere Sci IRCCS Santa Luc, CERC, Neurogenet Lab, I-00143 Rome, Italy
[2] Univ Roma Tor Vergata, Dipartimento Neurosci, I-00133 Rome, Italy
[3] Univ Perugia, Dipartimento Med Sperimentale & Sci Biochim, I-06126 Perugia, Italy
来源：
CURRENT MEDICINAL CHEMISTRY | 2010年 / 17卷 / 07期
关键词：
Embryonic Stem cells; Adult Stem Cells; induced Pluripotent stem cells; central and peripheral nervous system diseases; stem cell therapy; AMYOTROPHIC-LATERAL-SCLEROSIS; UMBILICAL-CORD-BLOOD; MARROW STROMAL CELLS; NEURAL PROGENITOR CELLS; ADULT BONE-MARROW; SELF-RENEWAL; MOUSE MODEL; DIRECTED DIFFERENTIATION; HUNTINGTONS-DISEASE; MICRORNA EXPRESSION;
D O I：
10.2174/092986710790416272
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In regenerative medicine, stem cells are currently considered ideal candidates for the treatment of diseases and injuries of the nervous system, for which, at present, there are no effective treatments. Promising results have been shown by clinical trials for neurodegenerative diseases such as Parkinson's diseases, but also for demyelinising disorders and traumatic lesions of the brain and spinal cord. The proof-of-principle is that the replacement of damaged cells and the restoration of function can be accomplished by the transplantation of embryonic or adult stem cells. Advancements in stem cell biology were recently propelled by the ability to generate induced pluripotent stem (iPS) cells from fibroblasts of several neurodegenerative diseases (e. g. Parkinson's and Huntington's diseases, Amyotrophic Lateral Sclerosis and Spinal Muscular Atrophy). In this review, we discuss the molecular basis of stem cell therapy and the advancement of research on regenerative medicine for diseases and injuries of the nervous system.
引用
收藏
页码：595 / 608
页数：14
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