Inflammation in the Pathophysiology and Therapy of Cardiometabolic Disease

被引：91

作者：

Donath, Marc Y. ^{[1
,2
]}

Meier, Daniel T. ^{[1
,2
]}

Boni-Schnetzler, Marianne ^{[1
,2
]}

机构：

[1] Univ Basel, Clin Endocrinol Diabet & Metab, CH-4031 Basel, Switzerland

[2] Univ Basel, Dept Biomed, CH-4031 Basel, Switzerland

来源：

ENDOCRINE REVIEWS | 2019年 / 40卷 / 04期

基金：

瑞士国家科学基金会;

关键词：

NECROSIS-FACTOR-ALPHA; ISLET AMYLOID POLYPEPTIDE; IL-1 RECEPTOR ANTAGONIST; BETA-CELL PROLIFERATION; OBESITY-INDUCED INFLAMMATION; C-REACTIVE PROTEIN; INSULIN SENSITIVITY; NLRP3; INFLAMMASOME; CARDIOVASCULAR OUTCOMES; RHEUMATOID-ARTHRITIS;

D O I：

10.1210/er.2019-00002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The role of chronic inflammation in the pathogenesis of type 2 diabetes mellitus and associated complications is now well established. Therapeutic interventions counteracting metabolic inflammation improve insulin secretion and action and glucose control and may prevent long-term complications. Thus, a number of anti-inflammatory drugs approved for the treatment of other inflammatory conditions are evaluated in patients with metabolic syndrome. Most advanced are clinical studies with IL-1 antagonists showing improved beta-cell function and glycemia and prevention of cardiovascular diseases and heart failure. However, alternative anti-inflammatory treatments, alone or in combinations, may turn out to be more effective, depending on genetic predispositions, duration, and manifestation of the disease. Thus, there is a great need for comprehensive and well-designed clinical studies to implement anti-inflammatory drugs in the treatment of patients with metabolic syndrome and its associated conditions.

引用

页码：1080 / 1091

页数：12

共 151 条

[1] Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment [J].

Amar, Jacques ;

Chabo, Chantal ;

Waget, Aurelie ;

Klopp, Pascale ;

Vachoux, Christelle ;

Bermudez-Humaran, Luis G. ;

Smirnova, Natalia ;

Berge, Mathieu ;

Sulpice, Thierry ;

Lahtinen, Sampo ;

Ouwehand, Arthur ;

Langella, Philippe ;

Rautonen, Nina ;

Sansonetti, Philippe J. ;

Burcelin, Remy .

EMBO MOLECULAR MEDICINE, 2011, 3 (09) :559-572

[2] Diabetes mellitus risk in rheumatoid arthritis: Reduced incidence with anti-tumor necrosis factor α therapy [J].

Antohe, Jana L. ;

Bili, Androniki ;

Sartorius, Jennifer A. ;

Kirchner, H. Lester ;

Morris, Stephanie J. ;

Dancea, Sorina ;

Wasko, Mary Chester M. .

ARTHRITIS CARE & RESEARCH, 2012, 64 (02) :215-221

[3] IL-37 protects against obesity-induced inflammation and insulin resistance [J].

Ballak, Dov B. ;

van Diepen, Janna A. ;

Moschen, Alexander R. ;

Jansen, Henry J. ;

Hijmans, Anneke ;

Groenhof, Gert-Jan ;

Leenders, Floris ;

Bufler, Philip ;

Boekschoten, Mark V. ;

Muller, Michael ;

Kersten, Sander ;

Li, Suzhao ;

Kim, SooHyun ;

Eini, Hadar ;

Lewis, Eli C. ;

Joosten, Leo A. B. ;

Tilg, Herbert ;

Netea, Mihai G. ;

Tack, Cees J. ;

Dinarello, Charles A. ;

Stienstra, Rinke .

NATURE COMMUNICATIONS, 2014, 5

[4] The spectrum of T cell metabolism in health and disease [J].

Bantug, Glenn R. ;

Galluzzi, Lorenzo ;

Kroemer, Guido ;

Hess, Christoph .

NATURE REVIEWS IMMUNOLOGY, 2018, 18 (01) :19-34

[5] Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression [J].

Bauernfeind, Franz G. ;

Horvath, Gabor ;

Stutz, Andrea ;

Alnemri, Emad S. ;

MacDonald, Kelly ;

Speert, David ;

Fernandes-Alnemri, Teresa ;

Wu, Jianghong ;

Monks, Brian G. ;

Fitzgerald, Katherine A. ;

Hornung, Veit ;

Latz, Eicke .

JOURNAL OF IMMUNOLOGY, 2009, 183 (02) :787-791

[6] CYTOTOXICITY OF HUMAN PI-7 INTERLEUKIN-1 FOR PANCREATIC-ISLETS OF LANGERHANS [J].

BENDTZEN, K ;

MANDRUPPOULSEN, T ;

NERUP, J ;

NIELSEN, JH ;

DINARELLO, CA ;

SVENSON, M .

SCIENCE, 1986, 232 (4757) :1545-1547

[7] Effects of etanercept in patients with the metabolic syndrome [J].

Bernstein, LE ;

Berry, J ;

Kim, S ;

Canavan, B ;

Grinspoon, SK .

ARCHIVES OF INTERNAL MEDICINE, 2006, 166 (08) :902-908

[8] Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I [J].

Boeni-Schnetzler, Marianne ;

Boller, Simone ;

Debray, Sarah ;

Bouzakri, Karim ;

Meier, Daniel T. ;

Prazak, Richard ;

Kerr-Conte, Julie ;

Pattou, Francois ;

Ehses, Jan A. ;

Schuit, Frans C. ;

Donath, Marc Y. .

ENDOCRINOLOGY, 2009, 150 (12) :5218-5229

[9] Increased interleukin (IL)-1β messenger ribonucleic acid expression in β-cells of individuals with type 2 diabetes and regulation of IL-1β in human islets by glucose and autostimulation [J].

Boni-Schnetzler, Marianne ;

Thorne, Jeffrey ;

Parnaud, Geraldine ;

Marselli, Lorella ;

Ehses, Jan A. ;

Kerr-Conte, Julie ;

Pattou, Francois ;

Halban, Philippe A. ;

Weir, Gordon C. ;

Donath, Marc Y. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (10) :4065-4074

[10] β Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs β Cell Proliferation and Insulin Secretion [J].

Boni-Schnetzler, Marianne ;

Hauselmann, Stephanie P. ;

Dalmas, Elise ;

Meier, Daniel T. ;

Thienel, Constanze ;

Traub, Shuyang ;

Schulze, Friederike ;

Steiger, Laura ;

Dror, Erez ;

Martin, Praxedis ;

Herrera, Pedro L. ;

Gabay, Cem ;

Donath, Marc Y. .

CELL REPORTS, 2018, 22 (07) :1774-1786

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