A one-step synthesis of 2-(2-pyridyl)-3H-indol-3-one N-oxide:: Is it an efficient spin trap for hydroxyl radical?

被引:52
作者
Rosen, GM [1 ]
Tsai, P
Barth, ED
Dorey, G
Casara, P
Spedding, M
Halpern, HJ
机构
[1] Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Baltimore, MD 21201 USA
[2] Univ Maryland, Inst Biotechnol, Ctr Med Biotechnol, Baltimore, MD 21201 USA
[3] Univ Chicago, Dept Radiat & Cellular Oncol, Chicago, IL 60637 USA
[4] Inst Rech Servier, F-7829 Croissy Sur Seine, France
关键词
D O I
10.1021/jo0006122
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:4460 / 4463
页数:4
相关论文
共 33 条
[1]   DESIGN OF MODIFIED PYRROLINE N-OXIDE DERIVATIVES AS SPIN TRAPS SPECIFIC FOR HYDROXYL RADICAL [J].
ARYA, P ;
STEPHENS, JC ;
GRILLER, D ;
POU, S ;
RAMOS, CL ;
POU, WS ;
ROSEN, GM .
JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (08) :2297-2301
[2]   ISATOGENS .6. SYNTHESIS OF ISATOGENS VIA TOLAN (DIPHENYLACETYLENE) INTERMEDIATES [J].
BOND, CC ;
HOOPER, M .
JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1969, (18) :2453-+
[3]  
BOND CC, 1974, SYNTHESIS-STUTTGART, P443
[4]   EXPERIMENTS TOWARDS THE SYNTHESIS OF CORRINS .2. THE PREPARATION AND REACTIONS OF DELTA-1-PYRROLINE 1-OXIDES [J].
BONNETT, R ;
BROWN, RFC ;
CLARK, VM ;
SUTHERLAND, IO ;
TODD, A .
JOURNAL OF THE CHEMICAL SOCIETY, 1959, (JUN) :2094-2102
[5]   PREPARATION OF ISATOGENS FROM 2-SUBSTITUTED INDOLINES [J].
BRISTOW, THC ;
FOSTER, HE ;
HOOPER, M .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1974, (17) :677-678
[6]   SPIN TRAPPING - ELECTRON-SPIN-RESONANCE PARAMETERS OF SPIN ADDUCTS [J].
BUETTNER, GR .
FREE RADICAL BIOLOGY AND MEDICINE, 1987, 3 (04) :259-303
[7]   FREE-RADICALS IN IRON-CONTAINING SYSTEMS [J].
DUNFORD, HB .
FREE RADICAL BIOLOGY AND MEDICINE, 1987, 3 (06) :405-421
[8]   SPIN TRAPPING - KINETICS OF THE REACTION OF SUPEROXIDE AND HYDROXYL RADICALS WITH NITRONES [J].
FINKELSTEIN, E ;
ROSEN, GM ;
RAUCKMAN, EJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (15) :4994-4999
[9]   5-(DIETHOXYPHOSPHORYL)-5-METHYL-1-PYRROLINE N-OXIDE - A NEW EFFICIENT PHOSPHORYLATED NITRONE FOR THE IN-VITRO AND IN-VIVO SPIN-TRAPPING OF OXYGEN-CENTERED RADICALS [J].
FREJAVILLE, C ;
KAROUI, H ;
TUCCIO, B ;
LEMOIGNE, F ;
CULCASI, M ;
PIETRI, S ;
LAURICELLA, R ;
TORDO, P .
JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (02) :258-265
[10]   BIOLOGY OF OXYGEN RADICALS [J].
FRIDOVICH, I .
SCIENCE, 1978, 201 (4359) :875-880