Immunohistochemical study of angiogenesis after local administration of platelet-rich plasma in a patellar tendon defect

被引：70
|
作者：
Lyras, Dimitris [1 ]
Kazakos, Kostas [1 ]
Verettas, Dionysios [1 ]
Polychronidis, Alexandros [2 ]
Simopoulos, Constantinos [2 ]
Botaitis, Sotirios [3 ]
Agrogiannis, George [4 ]
Kokka, Anna [4 ]
Patsouris, Efstratios [4 ]
机构：
[1] Democritus Univ Thrace, Orthopaed Clin, Alexandroupolis, Greece
[2] Democritus Univ Thrace, Dept Surg 2, Alexandroupolis, Greece
[3] Democritus Univ Thrace, Lab Expt Surg & Surg Res, Alexandroupolis, Greece
[4] Kapodistrian Univ Athens, Dept Pathol, Athens, Greece
来源：
INTERNATIONAL ORTHOPAEDICS | 2010年 / 34卷 / 01期
关键词：
ANTERIOR CRUCIATE LIGAMENT; ENDOTHELIAL GROWTH-FACTOR; ACHILLES-TENDON; FIBRIN MATRICES; STEM-CELLS; RECONSTRUCTION; REPAIR;
D O I：
10.1007/s00264-009-0728-y
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
A full thickness defect was made in the central portion of the patellar tendon of 48 New Zealand white rabbits. Platelet-rich plasma (PRP) gel was then applied and filled the tendon defect. The same procedure was performed in the control group, without the application of PRP. Animals were sacrificed after one, two, three, and four weeks. Histological and immunohistochemical analyses using a monoclonal antibody against CD31 were performed. The histological examination showed a superior healing process in the PRP group compared with the control group. Especially in the third week, the tissue formed in the PRP group was more mature and dense with less elastic fibres remaining. Neovascularisation was significantly higher in the PRP group during the first two weeks and significantly lower in the third and fourth weeks (p < 0.0001). Histological examination and study of angiogenesis showed that the application of PRP enhances and accelerates the tendon healing process.
引用
收藏
页码：143 / 148
页数：6
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