The role of chernokines and chemokine receptors in allo antigen-independent and allo antigen-dependent transplantation injury

被引：33

作者：

DeVries, ME

Hosiawa, KA

Cameron, CM

Bosinger, SE

Persad, D

Kelvin, AA

Coombs, JC

Wang, H

Zhong, R

Cameron, MJ

Kelvin, DJ

机构：

[1] Univ Toronto, Div Expt Therapeut, Univ Hlth Network, Tornoto Gen Res Inst, Toronto, ON M5G 2C4, Canada

[2] Univ Toronto, Dept Immunol, Univ Hlth Network, Tornoto Gen Res Inst, Toronto, ON M5G 2C4, Canada

[3] Univ Western Ontario, Dept Microbiol & Immunol, London, ON N6A 5C, Canada

[4] Univ Western Ontario, Dept Surg, London, ON N6A 5C1, Canada

[5] Univ Toronto, Dept Immunol, Toronto, ON M5S 1A8, Canada

来源：

SEMINARS IN IMMUNOLOGY | 2003年 / 15卷 / 01期

关键词：

chemokines; chemokine receptors; transplantation; transplantation injury; microarray;

D O I：

10.1016/S1044-5323(02)00126-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transplantation injury and rejection involves the interplay of innate and acquired immune responses. Immune-related injury manifests itself in three temporal phases: early innate immune driven alloantigen-independent injury, acquired immune driven alloantigen-dependent injury, and chronic injury. Sequential waves of chemokine expression play a central role in regulating graft injury through the recruitment of phagocytes shortly after transplantation and activated lymphocytes and phagocytes in the weeks and years following transplantation. This review focuses on recent studies demonstrating the role of chemokines in transplantation. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：33 / 48

页数：16

共 108 条

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