Clinical Characteristics, Frailty, and Mortality of Residents With COVID-19 in Nursing Homes of a Region of Madrid

被引:52
作者
Bielza, Rafael [1 ,2 ]
Sanz, Juan [3 ]
Zambrana, Francisco [2 ,4 ]
Arias, Estefania [1 ,2 ]
Malmierca, Eduardo [2 ,5 ]
Portillo, Laura [2 ,6 ]
Thuissard, Israel J. [2 ]
Lung, Ana [1 ,2 ]
Neira, Marta [1 ,2 ]
Moral, Maria [7 ]
Andreu-Vazquez, Cristina [2 ]
Esteban, Ana [8 ]
Irma Ramirez, Marcela [9 ]
Gonzalez, Laura [10 ]
Carretero, Guillermo [11 ]
Vicente Moreno, Ricardo [12 ]
Martinez, Pilar [12 ]
Lopez, Javier [2 ,12 ]
Esteban-Ortega, Mar [2 ,13 ]
Garcia, Isabel [2 ,13 ]
Antonia Vaquero, Maria [2 ,14 ]
Linares, Ana [2 ,15 ]
Gomez-Santana, Ana [16 ]
Gomez Cerezo, Jorge [2 ,5 ]
机构
[1] Hosp Univ Infanta Sofia San Sebastian Reyes, Dept Geriatr Med, Madrid, Spain
[2] Univ Europea Madrid, Dept Med, Fac Biomed & Hlth Sci, Madrid, Spain
[3] Hosp Univ Infanta Sofia San Sebastian Reyes, Dept Dermatol, Madrid, Spain
[4] Hosp Univ Infanta Sofia San Sebastian Reyes, Dept Oncol, Madrid, Spain
[5] Hosp Univ Infanta Sofia San Sebastian Reyes, Dept Internal Med, Madrid, Spain
[6] Hosp Univ Infanta Sofia San Sebastian Reyes, Dept Pharm, Madrid, Spain
[7] Hosp Univ Infanta Sofia San Sebastian Reyes, Dept Palliat Care, Madrid, Spain
[8] Hosp Univ Infanta Sofia San Sebastian Reyes, Dept Rheumatol, Madrid, Spain
[9] Hosp Univ Infanta Sofia San Sebastian Reyes, Dept Endocrinol, Madrid, Spain
[10] Hosp Univ Infanta Sofia San Sebastian Reyes, Dept Neurol, Madrid, Spain
[11] Hosp Univ Infanta Sofia San Sebastian Reyes, Dept Orthoped, Madrid, Spain
[12] Hosp Univ Infanta Sofia San Sebastian Reyes, Dept Rehabil, Madrid, Spain
[13] Hosp Univ Infanta Sofia San Sebastian Reyes, Dept Ophthalmol, Madrid, Spain
[14] Hosp Univ Infanta Sofia San Sebastian Reyes, Dept Gen Surg, Madrid, Spain
[15] Hosp Univ Infanta Sofia San Sebastian Reyes, Dept Urol, Madrid, Spain
[16] Hosp Univ Infanta Sofia San Sebastian Reyes, Dept Prevent Med, Madrid, Spain
关键词
Nursing homes; mortality; geriatric hospital-based team; clinical frailty score; CORONAVIRUS DISEASE 2019;
D O I
10.1016/j.jamda.2020.12.003
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objectives: To describe the clinical characteristics, 30-day mortality, and associated factors of patients living in nursing homes (NH) with COVID-19, from March 20 to June 1, 2020. Design: This is a retrospective study. A geriatric hospital-based team acted as a consultant and coordinated the care of older people living in NHs from the hospital. Setting and Participants: A total of 630 patients aged 70 and older with Coronavirus Disease 2019 COVID19 living in 55 NHs. Methods: A logistic regression was performed to analyze the factors associated with mortality. In addition, Kaplan-Meier curves were applied according to mortality and its associated factors using the logrank Mantel-Cox test. Results: The diagnosis of COVID-19 was mainly made by clinical compatibility (N = 430). Median age was 87 years, 64.6% were women and 45.9% were transferred to be cared for at the hospital. A total of 282 patients died (44.7%) within the 30 days of first attention by the team. A severe form of COVID-19 occurred in 473 patients, and the most frequent symptoms were dyspnea (n = 332) and altered level of consciousness (n = 301). According to multiple logistic regression, male sex (P = .019), the Clinical Frailty Score (CFS) >= 6 (P = .004), dementia (P = .012), dyspnea (P < .001), and having a severe form of COVID-19 (P = .001), were associated with mortality, whereas age and care setting were not. Conclusions and Implications: Mortality of the residents living in NHs with COVID-19 was almost 45%. The altered level of consciousness as an atypical presentation of COVID-19 should be considered in this population. A severe form of the disease, present in more than three-quarters of patients, was associated with mortality, apart from the male sex, CFS >= 6, dementia, and dyspnea, whereas age and care setting were not. These findings may also help to recognize patients in which the Advance Care Planning process is especially urgent to assist in the decisions about their care. (C) 2020 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
引用
收藏
页码:245 / +
页数:10
相关论文
共 31 条
[1]   Characteristics of US Nursing Homes withCOVID-19 Cases [J].
Abrams, Hannah R. ;
Loomer, Lacey ;
Gandhi, Ashvin ;
Grabowski, David C. .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2020, 68 (08) :1653-1656
[2]   Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected. Interim guidance [J].
不详 .
PEDIATRIA I MEDYCYNA RODZINNA-PAEDIATRICS AND FAMILY MEDICINE, 2020, 16 (01) :9-26
[3]   Death risk stratification in elderly patients with covid-19. A comparative cohort study in nursing homes outbreaks [J].
Bernabeu-Wittel, M. ;
Ternero-Vega, J. E. ;
Diaz-Jimenez, P. ;
Conde-Guzman, C. ;
Nieto-Martin, M. D. ;
Moreno-Gavino, L. ;
Delgado-Cuesta, J. ;
Rincon-Gomez, M. ;
Gimenez-Miranda, L. ;
Navarro-Amuedo, M. D. ;
Munoz-Garcia, M. M. ;
Calzon-Fernandez, S. ;
Ollero-Baturone, M. .
ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2020, 91
[4]   The Effect of Age on Mortality in Patients With COVID-19: A Meta-Analysis With 611,583 Subjects [J].
Bonanad, Clara ;
Garcia-Blas, Sergio ;
Tarazona-Santabalbina, Francisco ;
Sanchis, Juan ;
Bertomeu-Gonzalez, Vicente ;
Facila, Lorenzo ;
Ariza, Albert ;
Nunez, Julio ;
Cordero, Alberto .
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2020, 21 (07) :915-918
[5]   A Cohort of Patients with COVID-19 in a Major Teaching Hospital in Europe [J].
Borobia, Alberto M. ;
Carcas, Antonio J. ;
Arnalich, Francisco ;
Alvarez-Sala, Rodolfo ;
Monserrat-Villatoro, Jaime ;
Quintana, Manuel ;
Carlos Figueira, Juan ;
Torres Santos-Olmo, Rosario M. ;
Garcia-Rodriguez, Julio ;
Martin-Vega, Alberto ;
Buno, Antonio ;
Ramirez, Elena ;
Martinez-Ales, Gonzalo ;
Garcia-Arenzana, Nicolas ;
Concepcion Nunez, M. ;
Marti-de-Gracia, Milagros ;
Moreno Ramos, Francisco ;
Reinoso-Barbero, Francisco ;
Martin-Quiros, Alejandro ;
Rivera Nunez, Angelica ;
Mingorance, Jesus ;
Carpio Segura, Carlos J. ;
Prieto Arribas, Daniel ;
Rey Cuevas, Esther ;
Prados Sanchez, Concepcion ;
Rios, Juan J. ;
Hernan, Miguel A. ;
Frias, Jesus ;
Arribas, Jose R. .
JOURNAL OF CLINICAL MEDICINE, 2020, 9 (06) :1-10
[6]   Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study [J].
Chen, Nanshan ;
Zhou, Min ;
Dong, Xuan ;
Qu, Jieming ;
Gong, Fengyun ;
Han, Yang ;
Qiu, Yang ;
Wang, Jingli ;
Liu, Ying ;
Wei, Yuan ;
Xia, Jia'an ;
Yu, Ting ;
Zhang, Xinxin ;
Zhang, Li .
LANCET, 2020, 395 (10223) :507-513
[7]  
Cid-Ruzafa J, 1997, Rev Esp Salud Publica, V71, P127, DOI 10.1590/S1135-57271997000200004
[8]  
Comunidad de Madrid, CON SERV SOC
[9]   Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study [J].
Deng, Lisi ;
Li, Chunna ;
Zeng, Qi ;
Liu, Xi ;
Li, Xinghua ;
Zhang, Haitang ;
Hong, Zhongsi ;
Xia, Jinyu .
JOURNAL OF INFECTION, 2020, 81 (01) :E1-E5
[10]   Complementing chronic frailty assessment at hospital admission with an electronic frailty index (FI-Laboratory) comprising routine blood test results [J].
Ellis, Hugh Logan ;
Wan, Bettina ;
Yeung, Michael ;
Rather, Arshad ;
Mannan, Imran ;
Bond, Catherine ;
Harvey, Catherine ;
Raja, Nadia ;
Dutey-Magni, Peter ;
Rockwood, Kenneth ;
Davis, Daniel ;
Searle, Samuel D. .
CANADIAN MEDICAL ASSOCIATION JOURNAL, 2020, 192 (01) :E3-E8