A novel vaccine platform using glucan particles for induction of protective responses against Francisella tularensis and other pathogens

被引：19
作者：
Abraham, A. [1 ]
Ostroff, G. [1 ]
Levitz, S. M. [1 ]
Oyston, P. C. F. [2 ]
机构：
[1] Univ Massachusetts, Sch Med, Worcester, MA USA
[2] Def Sci & Technol Lab, CBR Div, Salisbury, Wilts, England
来源：
CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2019年 / 198卷 / 02期
基金：
美国国家卫生研究院;
关键词：
beta-glucans; fungal; tularemia; vaccine; CD4(+) T-CELLS; BETA-GLUCAN; PNEUMONIC TULAREMIA; TRAINED IMMUNITY; PROTEIN; ACTIVATION; ADJUVANT; ANTIBODY; DECTIN-1; ANTIGEN;
D O I：
10.1111/cei.13356
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Vaccines are considered the bedrock of preventive medicine. However, for many pathogens, it has been challenging to develop vaccines that stimulate protective, long-lasting immunity. We have developed a novel approach using beta-1,3-D-glucans (BGs), natural polysaccharides abundantly present in fungal cell walls, as a biomaterial platform for vaccine delivery. BGs simultaneously provide for receptor-targeted antigen delivery to specialized antigen-presenting cells together with adjuvant properties to stimulate antigen-specific and trained non-specific immune responses. This review focuses on various approaches of using BG particles (GPs) to develop bacterial and fungal vaccine candidates. A special case history for the development of an effective GP tularaemia vaccine candidate is highlighted.
引用
收藏
页码：143 / 152
页数：10
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