The DrugAge database of aging-related drugs

被引：118

作者：

Barardo, Diogo ^{[1
]}

Thornton, Daniel ^{[1
]}

Thoppil, Harikrishnan ^{[1
,2
]}

Walsh, Michael ^{[3
]}

Sharifi, Samim ^{[1
]}

Ferreira, Susana ^{[1
]}

Anzic, Andreja ^{[1
]}

Fernandes, Maria ^{[1
]}

Monteiro, Patrick ^{[1
]}

Grum, Tjasa ^{[1
]}

Cordeiro, Rui ^{[1
]}

De-Souza, Evandro Araujo ^{[4
]}

Budovsky, Arie ^{[5
,6
]}

Araujo, Natali ^{[1
]}

Gruber, Jan ^{[7
,8
]}

Petrascheck, Michael ^{[9
]}

Fraifeld, Vadim E. ^{[5
]}

Zhavoronkov, Alexander ^{[10
,11
]}

Moskalev, Alexey ^{[12
,13
,14
]}

de Magalhaes, Joao Pedro ^{[1
,11
]}

机构：

[1] Univ Liverpool, Inst Ageing & Chron Dis, Integrat Genom Ageing Grp, William Henry Duncan Bldg,Room 281, Liverpool L7 8TX, Merseyside, England

[2] Amrita Univ, Amrita Sch Biotechnol, Amrita Vishwa Vidyapeetham, Coimbatore, Tamil Nadu, India

[3] Swiss Fed Inst Technol, Energy Metab Lab, Zurich, Switzerland

[4] Univ Fed Sao Paulo, Dept Biophys, Sao Paulo, Brazil

[5] Ben Gurion Univ Negev, Shraga Segal Dept Microbiol Immunol & Genet, Ctr Multidisciplinary Res Aging, Beer Sheva, Israel

[6] Judea Reg Res & Dev Ctr, IL-90404 Carmel, Israel

[7] Yale NUS Coll, Dept Sci, Singapore 138527, Singapore

[8] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117597, Singapore

[9] Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA

[10] Johns Hopkins Univ Eastern, Pharmaceut Artificial Intelligence Res Div, Emerging Technol Ctr, Insilico Med Inc, B301,1101 33rd St, Baltimore, MD 21218 USA

[11] Biogerontol Res Fdn, Oxford, England

[12] Moscow Inst Phys & Technol, Dolgoprudnyi 141700, Russia

[13] Russian Acad Sci, Lab Mol Radiobiol & Gerontol, Inst Biol, Komi Sci Ctr,Ural Branch, Syktyvkar 167982, Russia

[14] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 119991, Russia

来源：

AGING CELL | 2017年 / 16卷 / 03期

基金：

英国惠康基金;

关键词：

bioinformatics; compound; functional genomics; lifespan; longevity; pharmacology;

D O I：

10.1111/acel.12585

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aging is a major worldwide medical challenge. Not surprisingly, identifying drugs and compounds that extend lifespan in model organisms is a growing research area. Here, we present DrugAge (http://genomics. senescence. info/drugs/), a curated database of lifespan-extending drugs and compounds. At the time of writing, DrugAge contains 1316 entries featuring 418 different compounds from studies across 27 model organisms, including worms, flies, yeast and mice. Data were manually curated from 324 publications. Using drug-gene interaction data, we also performed a functional enrichment analysis of targets of lifespan-extending drugs. Enriched terms include various functional categories related to glutathione and antioxidant activity, ion transport and metabolic processes. In addition, we found a modest but significant overlap between targets of lifespan-extending drugs and known aging-related genes, suggesting that some but not most aging-related pathways have been targeted pharmacologically in longevity studies. DrugAge is freely available online for the scientific community and will be an important resource for biogerontologists.

引用

页码：594 / 597

页数：4

共 6 条

[1] Genome-Environment Interactions That Modulate Aging: Powerful Targets for Drug Discovery [J].

de Magalhaes, Joao Pedro ;

Wuttke, Daniel ;

Wood, Shona H. ;

Plank, Michael ;

Vora, Chintan .

PHARMACOLOGICAL REVIEWS, 2012, 64 (01) :88-101

[2] AgeFactDB-the JenAge Ageing Factor Database-towards data integration in ageing research [J].

Huehne, Rolf ;

Thalheim, Torsten ;

Suehnel, Juergen .

NUCLEIC ACIDS RESEARCH, 2014, 42 (D1) :D892-D896

[3] Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic [J].

Moskalev, Alexey ;

Chernyagina, Elizaveta ;

Tsvetkov, Vasily ;

Fedintsev, Alexander ;

Shaposhnikov, Mikhail ;

Krut'ko, Vyacheslav ;

Zhavoronkov, Alex ;

Kennedy, Brian K. .

AGING CELL, 2016, 15 (03) :407-415

[4] Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease [J].

Moskalev, Alexey ;

Chernyagina, Elizaveta ;

de Magalhaes, Joao Pedro ;

Barardo, Diogo ;

Thoppil, Harikrishnan ;

Shaposhnikov, Mikhail ;

Budovsky, Arie ;

Fraifeld, Vadim E. ;

Garazha, Andrew ;

Tsvetkov, Vasily ;

Bronovitsky, Evgeny ;

Bogomolov, Vladislav ;

Scerbacov, Alexei ;

Kuryan, Oleg ;

Gurinovich, Roman ;

Jellen, Leslie C. ;

Kennedy, Brian ;

Mamoshina, Polina ;

Dobrovolskaya, Evgeniya ;

Aliper, Alex ;

Kaminsky, Dmitry ;

Zhavoronkov, Alex .

AGING-US, 2015, 7 (09) :616-628

[5] Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing [J].

Tacutu, Robi ;

Craig, Thomas ;

Budovsky, Arie ;

Wuttke, Daniel ;

Lehmann, Gilad ;

Taranukha, Dmitri ;

Costa, Joana ;

Fraifeld, Vadim E. ;

de Magalhaes, Joao Pedro .

NUCLEIC ACIDS RESEARCH, 2013, 41 (D1) :D1027-D1033

[6] DGIdb 2.0: mining clinically relevant drug-gene interactions [J].

Wagner, Alex H. ;

Coffman, Adam C. ;

Ainscough, Benjamin J. ;

Spies, Nicholas C. ;

Skidmore, Zachary L. ;

Campbell, Katie M. ;

Krysiak, Kilannin ;

Pan, Deng ;

McMichael, Joshua F. ;

Eldred, James M. ;

Walker, Jason R. ;

Wilson, Richard K. ;

Mardis, Elaine R. ;

Griffith, Malachi ;

Griffith, Obi L. .

NUCLEIC ACIDS RESEARCH, 2016, 44 (D1) :D1036-D1044

← 1 →