Platelet-Derived Growth Factor Is Involved in the Differentiation of Second Heart Field-Derived Cardiac Structures in Chicken Embryos

被引：25
作者：
Bax, Noortje A. M. [1 ]
Lie-Venema, Heleen [1 ]
Vicente-Steijn, Rebecca [1 ,2 ]
Bleyl, Steven B. [3 ,4 ]
Van Den Akker, Nynke M. S. [1 ]
Maas, Saskia [1 ]
Poelmann, Robert E. [1 ]
Gittenberger-de Groot, Adriana C. [1 ]
机构：
[1] Leiden Univ, Med Ctr, Dept Anat & Embryol, NL-2300 RC Leiden, Netherlands
[2] Leiden Univ, Med Ctr, Dept Cardiol, NL-2300 RC Leiden, Netherlands
[3] Univ Utah, Sch Med, Dept Pediat, Salt Lake City, UT USA
[4] Univ Utah, Sch Med, Dept Neurobiol & Anat, Salt Lake City, UT USA
来源：
DEVELOPMENTAL DYNAMICS | 2009年 / 238卷 / 10期
关键词：
chicken embryos; heart development; PDGF-A; PDGF-C; PDGFR-alpha; epicardium-derived cells; second heart field; VASCULAR SMOOTH-MUSCLE; IN-SITU HYBRIDIZATION; AVIAN HEART; ATRIOVENTRICULAR VALVES; EPICARDIAL OUTGROWTH; CORONARY-ARTERY; RECEPTOR-ALPHA; PATCH MOUSE; CELLS EPDCS; PDGF-C;
D O I：
10.1002/dvdy.22073
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
For the establishment of a fully functional septated heart, addition of myocardium from second heart field-derived structures is important. Platelet-derived growth factors (PDGFs) are known for their role in cardiovascular development. In this study, we aim to elucidate this role of PDGF-A, PDGF-C, and their receptor PDGFR-alpha. We analyzed the expression patterns of PDGF-A, PDGF-C, and their receptor PDGFR-alpha during avian heart development. A spatiotemporal pattern of ligands was seen with colocalization of the PDGFR-alpha. This was found in second heart field-derived myocardium as well as the proepicardial organ (PEO) and epicardium. Mechanical inhibition of epicardial outgrowth as well as chemical disturbance of PDGFR-alpha support a functional role of the ligands and the receptor in cardiac development. Developmental Dynamics 238.2658-2669, 2009. (c) 2009 Wiley-Liss, Inc.
引用
收藏
页码：2658 / 2669
页数：12
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