Transposon Silencing by piRNAs

被引：47
|
作者：
Halic, Mario [1 ,2 ]
Moazed, Danesh [1 ,2 ]
机构：
[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA
来源：
CELL | 2009年 / 138卷 / 06期
关键词：
DOMAIN PROTEIN; DROSOPHILA; RHINO; PIWI;
D O I：
10.1016/j.cell.2009.08.030
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In animal cells, small RNA molecules, called piRNAs, defend the genome against selfish DNA elements such as transposons. In this issue, Klattenhoff et al. (2009) report that an HP1 family protein, Rhino, is required for piRNA generation and transposon silencing in Drosophila germline cells. The results provide a link between heterochromatin and piRNA-mediated genome defense.
引用
收藏
页码：1058 / 1060
页数：3
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