Netrin-1 improves the amyloid-β-mediated suppression of memory and synaptic plasticity

被引：30

作者：

Shabani, Mohammad ^{[1
]}

Haghani, Masoud ^{[2
,3
]}

Tazangi, Parisa Esmaeili ^{[2
]}

Bayat, Mahnaz ^{[4
]}

Moosavi, Seyed Mostafa Shid ^{[2
]}

Ranjbar, Hoda ^{[1
]}

机构：

[1] Kerman Univ Med Sci, Neuropharmacol Inst, Neurosci Res Ctr, Kerman, Iran

[2] Shiraz Univ Med Sci, Dept Physiol, Shiraz 713651689, Iran

[3] Shiraz Univ Med Sci, Histomorphometry & Stereol Res Ctr, Shiraz, Iran

[4] Shiraz Univ Med Sci, Dept Physiol, Int Branch, Shiraz, Iran

来源：

BRAIN RESEARCH BULLETIN | 2017年 / 131卷

关键词：

Beta amyloid; Netrin-1; Long-term potentiation; Alzheimer's disease; LONG-TERM POTENTIATION; RECEPTOR ACTIVATION; PRECURSOR PROTEIN; LATE-PHASE; NEURONS; ISCHEMIA; TRANSMISSION; INHIBITION; EXPRESSION; APOPTOSIS;

D O I：

10.1016/j.brainresbull.2017.03.015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of this study was to investigate the effects of netrin-1 (NT-1) on amyloid-beta (A(3) induced impairments in learning-memory and synaptic plasticity. The NT-1 or its vehicle was administered four times into the A beta+ NT or A beta 3 + V groups, respectively. The A beta+ SNT group received a single dose of NT-1. The A beta+ HNT group received heat-inactivated NT-1. For the learning-memory and synaptic plasticity assessment, field potentials recording and behavioral experiment were used. Bilateral injection of A beta(1-42) inhibits induction of long-term potentiation (LTP) and decreased memory performance in all the behavioral tasks. However, only by repeated injection of NT-1, significant recovery of LTP and memory was seen. Although, the delivery of HFS to A beta+ NT group recovered EPSP slope of the maintenance phase when compared with A beta + V, but it failed to recover the induction phase. It can be assumed that NT-1 may have regulatory effects on the synthesis of key proteins and/or structural changes that are responsible for LTP induction, since the protein synthesis and/or structural changes are required for the maintenance phase of LTP.

引用

页码：107 / 116

页数：10

共 52 条

[51] Netrin-1 and kidney injury. I. Netrin-1 protects against ischemia-reperfusion injury of the kidney [J].