Investigation of linkage and association -: Issues on study design

被引：1

作者：

Bickeböller, H ^{[1
]}

机构：

[1] GSF, Natl Res Ctr Environm Hlth, Inst Epidemiol, Neuherberg, Germany

[2] Tech Univ Munich, Inst Med Stat & Epidemiol, D-8000 Munich, Germany

来源：

INTERNATIONAL STATISTICAL REVIEW | 2000年 / 68卷 / 01期

关键词：

association; complex disease; linkage; study design; TDT;

D O I：

10.2307/1403558

中图分类号：

O21 [概率论与数理统计]; C8 [统计学];

学科分类号：

020208 ; 070103 ; 0714 ;

摘要：

For the identification and description of susceptibility genes for complex diseases using genetic markers there are two basic strategies: genome scans or the investigation of candidate genes. The designs can be quite different for the two approaches and decide, more than in general epidemiology, the methods that can be applied subsequently. Study design, recruitment and sample size are discussed further in the context of the Transmission/Disequilibrium Test, a family-based simultaneous test for linkage and the context of the association.

引用

页码：75 / 81

页数：7

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