Ketogenic Diet and microRNAs Linked to Antioxidant Biochemical Homeostasis

被引：38

作者：

Cannataro, Roberto ^{[1
,2
]}

Caroleo, Maria Cristina ^{[2
]}

Fazio, Alessia ^{[2
]}

La Torre, Chiara ^{[2
]}

Plastina, Pierluigi ^{[2
]}

Gallelli, Luca ^{[3
]}

Lauria, Graziantonio ^{[2
]}

Cione, Erika ^{[2
]}

机构：

[1] Mater Domini Hosp, GalaScreen Labs, I-88100 Catanzaro, Italy

[2] Univ Calabria, Dept Pharm Hlth & Nutr Sci, Via Pietro Bucci, I-87036 Arcavacata Di Rende, CS, Italy

[3] Magna Graecia Univ Catanzaro, Mater Domini Hosp Catanzaro, Dept Hlth Sci, Clin Pharmacol & Pharmacovigilance Operat Unit, I-88100 Catanzaro, Italy

来源：

ANTIOXIDANTS | 2019年 / 8卷 / 08期

关键词：

ketogenic diet; microRNAs signature; catalase; TRANS-RETINOIC ACID; GENE-EXPRESSION; TGF-BETA; OBESITY; PROLIFERATION;

D O I：

10.3390/antiox8080269

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently, we demonstrated the capability of the ketogenic diet (KD) to influence the microRNA (miR) expression profile. Here, we report that KD is able to normalize miR expression in obese subjects when compared with lean subjects. By applying two different bioinformatics tools, we found that, amongst the miRs returning to comparable levels in lean subjects, four of them are linked to antioxidant biochemical pathways specifically, and the others are linked to both antioxidant and anti-inflammatory biochemical pathways. Of particular interest is the upregulation of hsa-miR-30a-5p, which correlates with the decrease of catalase expression protein in red blood cells.

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页数：10

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