Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals

被引：42

作者：

Hosseini, Seyede Atefe ^{[1
]}

Zahedipour, Fatemeh ^{[2
]}

Sathyapalan, Thozhukat ^{[3
]}

Jamialahmadi, Tannaz ^{[4
,5
]}

Sahebkar, Amirhossein ^{[6
,7
,8
,9
]}

机构：

[1] Mashhad Univ Med Sci, Student Res Comm, Fac Med, Mashhad, Iran

[2] Mashhad Univ Med Sci, Dept Med Biotechnol & Nanotechnol, Fac Med, Mashhad, Iran

[3] Univ Hull, Hull York Med Sch, Dept Acad Diabet Endocrinol & Metab, Kingston Upon Hull, N Humberside, England

[4] Islamic Azad Univ, Quchan Branch, Dept Food Sci & Technol, Quchan, Iran

[5] Mashhad Univ Med Sci, Dept Nutr, Fac Med, Mashhad, Iran

[6] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran

[7] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran

[8] Polish Mothers Mem Hosp Res Inst PMMHRI, Lodz, Poland

[9] FDA, Halal Res Ctr IRI, Tehran, Iran

来源：

BIOFACTORS | 2021年 / 47卷 / 03期

关键词：

curcumin; herbal medicine; lung; pulmonary fibrosis;

D O I：

10.1002/biof.1713

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pulmonary fibrosis (PF) is the devastating consequence of various inflammatory diseases of the lung. PF leads to a reduction of lung function, respiratory failure, and death. Several molecular pathways are involved in PF, such as inflammatory cytokines including tumor necrosis factor alpha (TNF alpha), tumor necrosis factor beta 1 (TNF beta 1), interleukin 6 (IL-6), and interleukin 4 (IL-4), reactive oxygen species, matrix metalloproteases, and transforming growth factor-beta (TGF-beta). Targeting these processes involved in the progression of PF is essential for the treatment of this disease. Natural products, including plant extracts and active compound that directly target the processes involved in PF, could be suitable therapeutic options with less adverse effects. In the present study, we reviewed the protective effects and the therapeutic role of various bioactive compounds from plants in PF management.

引用

页码：250 / 269

页数：20

共 166 条

[1] Nigella sativa, a traditional Tunisian herbal medicine, attenuates bleomycin-induced pulmonary fibrosis in a rat model [J].