Hypervalent Iodine Reagents: Thiol Derivatization with a Tetrafluoroethoxy Coumarin Residue for UV Absorbance Recognition

被引：12

作者：

Commare, Bruno ^{[1
]}

Togni, Antonio ^{[1
]}

机构：

[1] ETH, Dept Chem & Appl Biosci, Swiss Fed Inst Technol, Vladimir Prelog Weg 2, CH-8093 Zurich, Switzerland

来源：

HELVETICA CHIMICA ACTA | 2017年 / 100卷 / 05期

关键词：

Hypervalent iodine; Fluoroalkyl; Thiols; UV absorbance; Coumarins; ANGIOTENSIN-CONVERTING ENZYME; GLUTATHIONE; DESIGN; INHIBITORS; TRIFLUOROMETHYLATION; PENICILLAMINE; PROTEINS;

D O I：

10.1002/hlca.201700059

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new hypervalent iodine reagent (5) based on 1,2-dihydro-3,3-dimethyl-1,2-benziodoxole containing a 4-methyl7-tetrafluoroethoxycoumarin unit as a specific UV absorber was prepared and fully characterized, including X-ray crystal structural analysis. The high reactivity of this compound towards thiols has been exploited for the selective tagging of several targets with the UV chromophore coumarin, including e.g. glutathione.

引用

页数：7

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