Continuous Positive Airway Pressure in Patients With Obstructive Sleep Apnea and Resistant Hypertension: A Meta-Analysis of Randomized Controlled Trials

被引：107

作者：

Liu, Liping ^{[1
,2
]}

Cao, Qunan ^{[1
]}

Guo, Zhenzhen ^{[1
]}

Dai, Qiuyan ^{[1
]}

机构：

[1] Nanjing Med Univ, Shanghai Gen Hosp, Dept Cardiol, Shanghai, Peoples R China

[2] Nantong Med Univ, Affiliated Hosp 4, Yancheng People Hosp 1, Dept Cardiol, Nantong, Jiangsu, Peoples R China

来源：

JOURNAL OF CLINICAL HYPERTENSION | 2016年 / 18卷 / 02期

关键词：

PROFESSIONAL-EDUCATION COMMITTEE; AMBULATORY BLOOD-PRESSURE; SCIENTIFIC STATEMENT; CLINICAL-PRACTICE; UNITED-STATES; HEART HEALTH; ASSOCIATION; ALDOSTERONE; PREVALENCE; MORTALITY;

D O I：

10.1111/jch.12639

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

This study aimed to analyze the effect of continuous positive airway pressure (CPAP) on blood pressure (BP) in patients with obstructive sleep apnea (OSA) and resistant hypertension. Randomized controlled trials (RCTs) that evaluated the effect of CPAP on BP in patients with OSA and resistant hypertension, indexed in MEDLINE, Embase, and the Cochrane Library from inception until March 20, 2015, were included in the meta-analysis. A total of five RCTs were identified to meet the inclusion criteria. The pooled changes after CPAP treatment for 24-hour ambulatory systolic BP and diastolic BP (DBP) were -4.78mmHg (95% confidence interval [CI], -7.95 to -1.61) and -2.95mmHg (95% CI, -5.37 to -0.53) in favor of the CPAP group. CPAP was also associated with reduction in nocturnal DBP (mean difference, -1.53mmHg, 95% CI, -3.07 to 0). The results indicated a favorable reduction in BP with CPAP treatment in patients with OSA and resistant hypertension. (C) 2015 Wiley Periodicals, Inc.

引用

页码：153 / 158

页数：6

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