Potential Targets for Antifungal Drug Discovery Based on Growth and Virulence in Candida albicans

被引：34
作者：
Li, Xiuyun [1 ]
Hou, Yinglong [2 ]
Yue, Longtao [3 ]
Liu, Shuyuan [1 ]
Du, Juan [3 ]
Sun, Shujuan [4 ]
机构：
[1] Shandong Univ, Sch Pharmaceut Sci, Jinan 250100, Shandong, Peoples R China
[2] Shandong Univ, Qianfoshan Hosp, Dept Cardiol, Jinan 250100, Shandong, Peoples R China
[3] Shandong Univ, Qianfoshan Hosp, Translat Med Res Ctr, Jinan 250100, Shandong, Peoples R China
[4] Shandong Univ, Dept Pharm, Qianfoshan Hosp, Jinan 250100, Shandong, Peoples R China
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 10期
关键词：
OXIDATIVE STRESS-RESPONSE; PROTEIN-KINASE PATHWAY; TRANSCRIPTION FACTOR; HYPHAL DEVELOPMENT; BIOFILM FORMATION; GLYOXYLATE CYCLE; ISOCITRATE LYASE; INVASIVE CANDIDIASIS; SIGNALING PATHWAY; CYCLOSPORINE-A;
D O I：
10.1128/AAC.00726-15
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Fungal infections, especially infections caused by Candida albicans, remain a challenging problem in clinical settings. Despite the development of more-effective antifungal drugs, their application is limited for various reasons. Thus, alternative treatments with drugs aimed at novel targets in C. albicans are needed. Knowledge of growth and virulence in fungal cells is essential not only to understand their pathogenic mechanisms but also to identify potential antifungal targets. This article reviews the current knowledge of the mechanisms of growth and virulence in C. albicans and examines potential targets for the development of new antifungal drugs.
引用
收藏
页码：5885 / 5891
页数：7
相关论文
共 50 条
  • [41] The synergistic antifungal effects of sodium phenylbutyrate combined with azoles against Candida albicans via the regulation of the Ras-cAMP-PKA signalling pathway and virulence
    Sun, Wenwen
    Zhang, Liuping
    Lu, Xiaoyan
    Feng, Lei
    Sun, Shujuan
    [J]. CANADIAN JOURNAL OF MICROBIOLOGY, 2019, 65 (02) : 105 - 115
  • [42] Signal Transduction Proteins in Acinetobacter baumannii: Role in Antibiotic Resistance, Virulence, and Potential as Drug Targets
    De Silva, P. Malaka
    Kumar, Ayush
    [J]. FRONTIERS IN MICROBIOLOGY, 2019, 10
  • [43] Silver nanoparticles induced alterations in multiple cellular targets, which are critical for drug susceptibilities and pathogenicity in fungal pathogen (Candida albicans)
    Radhakrishnan, Venkatraman Srinivasan
    Mudiam, Mohana Krishna Reddy
    Kumar, Manish
    Dwivedi, Surya Prakash
    Singh, Surinder Pal
    Prasad, Tulika
    [J]. INTERNATIONAL JOURNAL OF NANOMEDICINE, 2018, 13 : 2647 - 2663
  • [44] A novel anti Candida albicans drug screening system based on high-throughput microfluidic chips
    Qiang, Le
    Guo, Jing
    Han, Yingkuan
    Jiang, Jianfeng
    Su, Xiaowen
    Liu, Hong
    Qi, Qingguo
    Han, Lin
    [J]. SCIENTIFIC REPORTS, 2019, 9 (1)
  • [45] Discovery of BRD4-HDAC Dual Inhibitors with Improved Fungal Selectivity and Potent Synergistic Antifungal Activity against Fluconazole-Resistant Candida albicans
    Li, Zhuang
    Huang, Yahui
    Tu, Jie
    Yang, Wanzhen
    Liu, Na
    Wang, Wei
    Sheng, Chunquan
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2023, 66 (08) : 5950 - 5964
  • [46] Dynamic nitric oxide/drug codelivery system based on polyrotaxane architecture for effective treatment of Candida albicans infection
    Li, Guowei
    Lv, Kai
    Pan, Xiangjun
    Zhou, Siting
    Xing, Hui
    Xu, Jun
    Ma, Dong
    Hu, Yunfeng
    Xu, Hao
    [J]. ACTA BIOMATERIALIA, 2023, 155 : 618 - 634
  • [47] Systematic Complex Haploinsufficiency-Based Genetic Analysis of Candida albicans Transcription Factors: Tools and Applications to Virulence-Associated Phenotypes
    Glazier, Virginia E.
    Murante, Thomas
    Koselny, Kristy
    Murante, Daniel
    Esqueda, Marisol
    Wall, Gina A.
    Wellington, Melanie
    Hung, Chiung-Yu
    Kumar, Anuj
    Krysan, Damian J.
    [J]. G3-GENES GENOMES GENETICS, 2018, 8 (04): : 1299 - 1314
  • [48] Evaluation of anti-Candida potential of geranium oil constituents against clinical isolates of Candida albicans differentially sensitive to fluconazole: inhibition of growth, dimorphism and sensitization
    Zore, Gajanan B.
    Thakre, Archana D.
    Rathod, V.
    Karuppayil, S. Mohan
    [J]. MYCOSES, 2011, 54 (04) : E99 - E109
  • [49] Discovery of potential asthma targets based on the clinical efficacy of Traditional Chinese Medicine formulas
    Wang, Yu
    Chen, Yan-Jiao
    Xiang, Cheng
    Jiang, Guang-Wei
    Xu, Yu-Dong
    Yin, Lei-Miao
    Zhou, Dong-Dong
    Liu, Yan-Yan
    Yang, Yong-Qing
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 2020, 252
  • [50] Adenylyl Cyclase and Protein Kinase A Play Redundant and Distinct Roles in Growth, Differentiation, Antifungal Drug Resistance, and Pathogenicity of Candida auris
    Kim, Ji-Seok
    Lee, Kyung-Tae
    Ha Lee, Myung
    Cheong, Eunji
    Bahn, Yong-Sun
    [J]. MBIO, 2021, 12 (05):
12345