A study of the properties of the C protein from skeletal and cardiac muscles of ground squirrel Citellus undulatus at different stages of the hibernation

被引：0

作者：

Vikhlyantsev, IM ^{[1
]}

Alekseeva, YA ^{[1
]}

Shpagina, MD ^{[1
]}

Udaltsov, SN ^{[1
]}

Podlubnaya, ZA ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Theoret & Expt Biophys, Pushchino 142290, Moscow Region, Russia

来源：

BIOFIZIKA | 2002年 / 47卷 / 04期

关键词：

skeletal muscle; cardiac muscle; hibernation; C protein; X protein;

D O I：

暂无

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Changes in the molecular weight and functional properties of the C and X proteins from skeletal muscles and the C protein from the cardiac muscle of hibernating ground squirrels Citellus undulatus. at different stages of the hibernation were studied. A decrease in the molecular weight of the, C. protein from fast fibers of skeletal muscles of hibernating ground squirrels compared with awakening and active animals was revealed. The appearance of shorter molecules of the C protein upon hibernation was accompanied by a lowering of its capacity to enhance. the actin-activated ATPase activity of control myosin and by the inhibition of its Ca2+-sensitivity. No similar changes were observed for the skeletal X protein and the cardiac C protein. The influence of the skeletal C protein on the main functional properties of myosin allows one to draw a conclusion about its contribution to the inhibition of contractile activity of skeletal muscles upon hibernation. The physiological significance of the changes in the C protein upon hibernation is-discussed in connection with similar changes in some cardiomyopathies.

引用

页码：701 / 705

页数：5

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