Biodistribution imaging of magnetic particles in mice: X-ray scanning analytical microscopy and magnetic resonance imaging

被引：7

作者：

Abe, Shigeaki ^{[1
]}

Kida, Ikuhiro ^{[2
]}

Esaki, Mitsue ^{[3
,4
]}

Akasaka, Tsukasa ^{[1
]}

Uo, Motohiro ^{[1
]}

Hosono, Toshiaki ^{[5
]}

Sato, Yoshinori ^{[5
]}

Jeyadevan, Balachandran ^{[5
]}

Kuboki, Yoshinori ^{[1
,6
]}

Morita, Manabu ^{[4
]}

Tohji, Kazuyuki ^{[5
]}

Watari, Fumio ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Dent Med, Dept Biomed Mat & Engn, Sapporo, Hokkaido 0608586, Japan

[2] Hokkaido Univ, Grad Sch Dent Med, Dept Oral Physiol, Sapporo, Hokkaido 0608586, Japan

[3] Hokkaido Univ, Grad Sch Dent Med, Dept Prevent Dent, Sapporo, Hokkaido 0608586, Japan

[4] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Oral Hlth, Okayama, Japan

[5] Tohoku Univ, Grad Sch Environm Studies, Sendai, Miyagi 980, Japan

[6] Koken Biosci Inst, Tokyo, Japan

来源：

BIO-MEDICAL MATERIALS AND ENGINEERING | 2009年 / 19卷 / 2-3期

关键词：

Biodistribution; magnetic resonance imaging; nano magnetite; CARBON NANOTUBES; SOFT-TISSUE; IN-VIVO; VISUALIZATION; TITANIUM;

D O I：

10.3233/BME-2009-0583

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Nano-sized particles have received much attention in view of their varied application in a wide range of fields. For example, magnetite (Fe3O4) nanoparticles have been investigated for various medical applications. In this study, we visualized the distribution of administered magnetic nanoparticles in mice using both X-ray scanning analytical microscopy (XSAM) and magnetic resonance imaging (MRI). After administration, the nanoparticles were rapidly dispersed via the blood circulation, and reached the liver, kidney and spleen. Using the XSAM and MRI methods in a complementary fashion, the biodistribution of nano-sized magnetite particles was successfully visualized.

引用

页码：213 / 220

页数：8

共 21 条

[1] Internal distribution of several inorganic microparticles in mice [J].

Abe, Shigeaki ;

Koyama, Chika ;

Akasaka, Tsukasa ;

Uo, Motohiro ;

Kuboki, Yoshinori ;

Watari, Fumio .

BIOCERAMICS 21, 2009, 396-398 :539-542

[2] Time-Dependence and Visualization of TiO2 and Pt Particle Biodistribution in Mice [J].

Abe, Shigeaki ;

Koyama, Chika ;

Uo, Motohiro ;

Akasaka, Tsukasa ;

Kuboki, Yoshinobu ;

Watari, Fumio .

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2009, 9 (08) :4988-4991

[3]

[Anonymous], 2007, PART FIBRE TOXICOL, DOI DOI 10.1186/1743-8977-4-2

[4] Synthesis and size classification of metal oxide nanoparticles for biomedical applications [J].

Atsumi, T ;

Jeyadevan, B ;

Sato, Y ;

Tamura, K ;

Aiba, S ;

Tohji, K .

NANOSENSING: MATERIALS AND DEVICES, 2004, 5593 :628-636

[5] Heating efficiency of magnetite particles exposed to AC magnetic field [J].

Atsumi, Takashi ;

Jeyadevan, Balachandran ;

Sato, Yoshinori ;

Tohji, Kazuyuki .

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2007, 310 (02) :2841-2843

[6] Biocompatibility and toxicological studies of carbon nanotubes doped with nitrogen [J].

Institute de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Cd. Universitaria, 04510, México, D.F. ;

不详 .

Nano Lett., 2006, 8 (1609-1616) :1609-1616

[7]

HOSONO T, 2007, THESIS TOHOKU U

[8] Platinum nanoflowers for surface-assisted laser desorption/ionization mass spectrometry of biomolecules [J].

Kawasaki, Hideya ;

Yonezawa, Tetsu ;

Watanabe, Takehiro ;

Arakawa, Ryuichi .

JOURNAL OF PHYSICAL CHEMISTRY C, 2007, 111 (44) :16278-16283

[9] Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping [J].

Kim, S ;

Lim, YT ;

Soltesz, EG ;

De Grand, AM ;

Lee, J ;

Nakayama, A ;

Parker, JA ;

Mihaljevic, T ;

Laurence, RG ;

Dor, DM ;

Cohn, LH ;

Bawendi, MG ;

Frangioni, JV .

NATURE BIOTECHNOLOGY, 2004, 22 (01) :93-97

[10] The MR tracking of transplanted ATDC5 cells using fluorinated poly L-lysine-CF3 [J].

Maki, Junichi ;

Masuda, Chiaki ;

Morikawa, Shigehiro ;

Morita, Masahito ;

Inubushi, Toshiro ;

Matsusue, Yoshitaka ;

Taguchi, Hiroyasu ;

Tooyama, Ikuo .

BIOMATERIALS, 2007, 28 (03) :434-440

← 1 2 3 →