Interaction of ACE2 and integrin β1 in failing human heart

被引：36
作者：
Lin, QS
Keller, RS
Weaver, B
Zisman, LS
机构：
[1] Myomatrix Therapeut, Rensselaer, NY 12144 USA
[2] Univ Albany, Ctr Funct Genom, Rensselaer, NY USA
[3] Albany Med Coll, Cardiovasc Res Ctr, Albany, NY 12208 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2004年 / 1689卷 / 03期
关键词：
angiotensin-converting enzyme 2; angiotensin-(1-7); heart failure; cardiomyopathy; integrin beta 1;
D O I：
10.1016/j.bbadis.2004.05.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
ACE2 purified from failing human heart was found to form a complex with integrin beta1 by immunoprecipitation, Western blotting, activity assay, and ESI tandem mass spectroscopy. The ACE2/integrin complex showed a K-m of 6.8 muM and a V-max of 2.13 pmol/min/mul purified enzyme. Activity was optimal at pH 7.5 with Ang II substrate. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：175 / 178
页数：4
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