Chromosomal β-lactamase is packaged into membrane vesicles and secreted from Pseudomonas aeruginosa

被引：212
|
作者：
Ciofu, O
Beveridge, TJ
Kadurugamuwa, J
Walther-Rasmussen, J
Hoiby, N
机构：
[1] Univ Copenhagen, Inst Med Microbiol & Immunol, Panum Inst 24 1, DK-2200 Copenhagen N, Denmark
[2] Univ Guelph, Dept Microbiol, Guelph, ON N1G 2W1, Canada
来源：
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2000年 / 45卷 / 01期
关键词：
D O I：
10.1093/jac/45.1.9
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Membrane vesicles were isolated from one beta-lactam-sensitive and three beta-lactam-resistant Pseudomonas aeruginosa clinical isolates from patients with cystic fibrosis. The presence of the chromosomally encoded beta-lactamase in the membrane vesicles was shown by electron microscopy and enzymatic studies. This is the first report of extracellular secretion of beta-lactamase in P. aeruginosa and it seems that the enzyme is packaged into membrane vesicles.
引用
收藏
页码：9 / 13
页数：5
相关论文
共 50 条
  • [31] INVESTIGATION OF THE PSEUDOMONAS-AERUGINOSA-AMPR GENE AND ITS ROLE AT THE CHROMOSOMAL AMPC BETA-LACTAMASE PROMOTER
    LODGE, J
    BUSBY, S
    PIDDOCK, L
    FEMS MICROBIOLOGY LETTERS, 1993, 111 (2-3) : 315 - 319
  • [32] Rapid development in vitro and in vivo of resistance to ceftazidime in biofilm-growing Pseudomonas aeruginosa due to chromosomal β-lactamase
    Bagge, N
    Ciofu, O
    Skovgaard, LT
    Hoiby, N
    APMIS, 2000, 108 (09) : 589 - 600
  • [33] RESISTANCE OF PSEUDOMONAS-AERUGINOSA MUTANTS WITH ALTERED CONTROL OF CHROMOSOMAL BETA-LACTAMASE TO PIPERACILLIN, CEFTAZIDIME, AND CEFSULODIN
    BRYAN, LE
    KWAN, S
    GODFREY, AJ
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1984, 25 (03) : 382 - 384
  • [34] The influence of allotypes on the IgG subclass response to chromosomal beta-lactamase of Pseudomonas aeruginosa in cystic fibrosis patients
    Ciofu, O
    Pressler, T
    Pandey, JP
    Hoiby, N
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1997, 108 (01): : 88 - 94
  • [35] Interplay between chromosomal β-lactamase and the MexAB-OprM efflux system in intrinsic resistance to β-lactams in Pseudomonas aeruginosa
    Masuda, N
    Gotoh, N
    Ishii, C
    Sakagawa, E
    Ohya, S
    Nishino, T
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (02) : 400 - 402
  • [36] The roles of the quorum-sensing system in the release of extracellular DNA, lipopolysaccharide, and membrane vesicles from Pseudomonas aeruginosa
    Nakamura, Shigeki
    Higashiyama, Yasuhito
    Izumikawa, Koichi
    Seki, Masafumi
    Kakeya, Hiroshi
    Yamamoto, Yoshihiro
    Yanagihara, Katsunori
    Miyazaki, Yoshitsugu
    Mizuta, Yohei
    Kohno, Shigeru
    JAPANESE JOURNAL OF INFECTIOUS DISEASES, 2008, 61 (05) : 375 - 378
  • [37] Membrane vesicles from Pseudomonas aeruginosa activate the noncanonical inflammasome through caspase-5 in human monocytes
    Bitto, Natalie J.
    Baker, Paul J.
    Dowling, Jennifer K.
    Wray-McCann, Georgie
    De Paoli, Amanda
    Le Son Tran
    Leung, Pak Ling
    Stacey, Katryn J.
    Mansell, Ashley
    Masters, Seth L.
    Ferrero, Richard L.
    IMMUNOLOGY AND CELL BIOLOGY, 2018, 96 (10): : 1120 - 1130
  • [38] Prophylactic and therapeutic vaccine against Pseudomonas aeruginosa keratitis using bacterial membrane vesicles
    Ito, Saori
    Nakamura, Jutaro
    Fukuta, Michiko
    Ura, Takehiro
    Teshigawara, Takeshi
    Fukushima, Jun
    Mizuki, Nobuhisa
    Okuda, Kenji
    Shimada, Masaru
    VACCINE, 2021, 39 (23) : 3152 - 3160
  • [39] Tobramycin reduces key virulence determinants in the proteome of Pseudomonas aeruginosa outer membrane vesicles
    Koeppen, Katja
    Barnaby, Roxanna
    Jackson, Angelyca A.
    Gerber, Scott A.
    Hogan, Deborah A.
    Stanton, Bruce A.
    PLOS ONE, 2019, 14 (01):
  • [40] Bacteriolytic effect of membrane vesicles from Pseudomonas aeruginosa on other bacteria including pathogens: Conceptually new antibiotics
    Kadurugamuwa, JL
    Beveridge, TJ
    JOURNAL OF BACTERIOLOGY, 1996, 178 (10) : 2767 - 2774
12345