Chromosomal β-lactamase is packaged into membrane vesicles and secreted from Pseudomonas aeruginosa

被引：212
|
作者：
Ciofu, O
Beveridge, TJ
Kadurugamuwa, J
Walther-Rasmussen, J
Hoiby, N
机构：
[1] Univ Copenhagen, Inst Med Microbiol & Immunol, Panum Inst 24 1, DK-2200 Copenhagen N, Denmark
[2] Univ Guelph, Dept Microbiol, Guelph, ON N1G 2W1, Canada
来源：
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2000年 / 45卷 / 01期
关键词：
D O I：
10.1093/jac/45.1.9
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Membrane vesicles were isolated from one beta-lactam-sensitive and three beta-lactam-resistant Pseudomonas aeruginosa clinical isolates from patients with cystic fibrosis. The presence of the chromosomally encoded beta-lactamase in the membrane vesicles was shown by electron microscopy and enzymatic studies. This is the first report of extracellular secretion of beta-lactamase in P. aeruginosa and it seems that the enzyme is packaged into membrane vesicles.
引用
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页码：9 / 13
页数：5
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