Chromosomal β-lactamase is packaged into membrane vesicles and secreted from Pseudomonas aeruginosa

被引：214

作者：

Ciofu, O

Beveridge, TJ

Kadurugamuwa, J

Walther-Rasmussen, J

Hoiby, N

机构：

[1] Univ Copenhagen, Inst Med Microbiol & Immunol, Panum Inst 24 1, DK-2200 Copenhagen N, Denmark

[2] Univ Guelph, Dept Microbiol, Guelph, ON N1G 2W1, Canada

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2000年 / 45卷 / 01期

关键词：

D O I：

10.1093/jac/45.1.9

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Membrane vesicles were isolated from one beta-lactam-sensitive and three beta-lactam-resistant Pseudomonas aeruginosa clinical isolates from patients with cystic fibrosis. The presence of the chromosomally encoded beta-lactamase in the membrane vesicles was shown by electron microscopy and enzymatic studies. This is the first report of extracellular secretion of beta-lactamase in P. aeruginosa and it seems that the enzyme is packaged into membrane vesicles.

引用

页码：9 / 13

页数：5

共 18 条

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