The effects of Ramadan fasting on serum concentrations of vaspin and omentin-1 in patients with nonalcoholic fatty liver disease

被引:12
作者
Ebrahimi, Sara [1 ,2 ]
Gargari, Bahram Pourghassem [3 ]
Izadi, Azimeh [3 ,4 ]
Imani, Bahareh [5 ]
Asjodi, Foad [6 ]
机构
[1] Jahrom Univ Med Sci, Motahari Hosp, Jahrom, Iran
[2] Deakin Univ, Fac Hlth Sci, Sch Exercise & Nutr Sci, Geelong, Vic, Australia
[3] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Dept Biochem & Diet Therapy, Tabriz, Iran
[4] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran
[5] Mashhad Univ Med Sci, Mashhad, Iran
[6] IFMARC, Tehran, Iran
关键词
Nonalcoholic fatty liver disease (NAFLD); Fasting Ramadan; Vaspin; Omentin-1; Non randomised clinical trial; INSULIN-RESISTANCE; CIRCULATING VASPIN; ADIPOSE-TISSUE; WEIGHT-LOSS; INFLAMMATION; SENSITIVITY; ADIPONECTIN; METABOLISM; CHEMERIN; NAFLD;
D O I
10.1016/j.eujim.2018.03.002
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Introduction: Nonalcoholic fatty liver disease (NAFLD) is the most frequent liver disease. Vaspin may modulate the inflammatory process, insulin resistance, and NAFLD. Omentin-1 is independently associated with hepatocyte ballooning. There is evidence of improvement in the adipokines level and histological hepatic steatosis following energy intake restriction and weight loss. The aim of the study was to evaluate the effects of Ramadan fasting on various circulating adipokines in NAFLD patients. Methods: This study was conducted on 83 NAFLD patients, 42 cases who declared that they would fast during the month of Ramadan fasted and 41 controls who decided not to fast during Ramadan. Anthropometric parameters including weight, body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR) and body fat percentage were measured before and after Ramadan. Dietary intake and physical activity levels were assessed by 24-h recall questionnaire and International physical activity questionnaire-short form (IPAQ-S), respectively. Serum adipokines including vaspin and omentin-1 were measured using commercial ELISA kit. Results: Patients who fasted displayed a lower mean hip circumference and body mass index and considerable changes in serum vaspin and omentin-1 (p-value < 0.05). The stepwise multivariate linear regression model revealed that the changes in weight, WHR, and dietary intakes were significant predictors of changes in serum adipokines. Conclusion: There is a potential for fasting in improving several anthropometric indices in NAFLD patients. Additionally, fasting during Ramadan resulted in decreased levels of adipokines including vaspin and omentin-1. Studies with longer follow-up periods are required.
引用
收藏
页码:110 / 114
页数:5
相关论文
共 30 条
  • [1] Serum levels of vaspin, obestatin, and apelin-36 in patients with nonalcoholic fatty liver disease
    Aktas, Bilge
    Yilmaz, Yusuf
    Eren, Fatih
    Yonal, Oya
    Kurt, Ramazan
    Alandab, Yesim Ozen
    Celikel, Cigdem Ataizi
    Ozdogan, Osman
    Imeryuz, Nese
    Kalayci, Cem
    Avsar, Erol
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 2011, 60 (04): : 544 - 549
  • [2] The Effects of Ramadan Fasting on Body Composition, Blood Pressure, Glucose Metabolism, and Markers of Inflammation in NAFLD Patients: An Observational Trial
    Aliasghari, Fereshteh
    Izadi, Azimeh
    Gargari, Bahram Pourghassem
    Ebrahimi, Sara
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 2017, 36 (08) : 640 - 645
  • [3] New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women
    Auguet, Teresa
    Quintero, Yunuen
    Riesco, David
    Morancho, Beatriz
    Terra, Ximena
    Crescenti, Anna
    Broch, Montserrat
    Aguilar, Carmen
    Olona, Montserrat
    Antonio Porras, Jose
    Hernandez, Merce
    Sabench, Fatima
    del Castillo, Daniel
    Richart, Cristobal
    [J]. BMC MEDICAL GENETICS, 2011, 12
  • [4] Nonalcoholic Fatty Liver Disease (NAFLD) Activity Score and the Histopathologic Diagnosis in NAFLD: Distinct Clinicopathologic Meanings
    Brunt, Elizabeth M.
    Kleiner, David E.
    Wilson, Laura A.
    Belt, Patricia
    Neuschwander-Tetri, Brent A.
    [J]. HEPATOLOGY, 2011, 53 (03) : 810 - 820
  • [5] The effects of prolonged fasting on the levels of adiponectin, leptin, apelin, and omentin in pregnant women
    Caglayan, Emel Kiyak
    Engin-Ustun, Yaprak
    Sari, Nagihan
    Gocmen, Ayse Yesim
    Polat, M. Fevzi
    [J]. JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2016, 36 (04) : 555 - 558
  • [6] Effects of Weight Reduction on Serum Vaspin Concentrations in Obese Subjects: Modification by Insulin Resistance
    Chang, Hye M.
    Lee, Hea J.
    Park, Hye S.
    Kang, Jae H.
    Kim, Kyung S.
    Song, Young S.
    Jang, Yeon J.
    [J]. OBESITY, 2010, 18 (11) : 2105 - 2110
  • [7] Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects
    Clément, K
    Viguerie, N
    Poitou, C
    Carette, C
    Pelloux, V
    Curat, CA
    Sicard, A
    Rome, S
    Benis, A
    Zucker, JD
    Vidal, H
    Laville, M
    Barsh, GS
    Basdevant, A
    Stich, V
    Cancello, R
    Langin, D
    [J]. FASEB JOURNAL, 2004, 18 (14) : 1657 - 1669
  • [8] Oral Coenzyme Q10 Supplementation in Patients with Nonalcoholic Fatty Liver Disease: Effects on Serum Vaspin, Chemerin, Pentraxin 3, Insulin Resistance and Oxidative Stress
    Farhangi, Mahdieh Abbasalizad
    Alipour, Beytollah
    Jafarvand, Elnaz
    Khoshbaten, Manouchehr
    [J]. ARCHIVES OF MEDICAL RESEARCH, 2014, 45 (07) : 589 - 595
  • [9] Intermittent fasting during Ramadan attenuates proinflammatory cytokines and immune cells in healthy subjects
    Faris, 'Mo'ez Al-Islam' E.
    Kacimi, Safia
    Al-Kurd, Ref'at A.
    Fararjeh, Mohammad A.
    Bustanji, Yasser K.
    Mohammad, Mohammad K.
    Salem, Mohammad L.
    [J]. NUTRITION RESEARCH, 2012, 32 (12) : 947 - 955
  • [10] Circulating vaspin and its relationship with insulin sensitivity, adiponectin, and liver histology in subjects with non-alcoholic steatohepatitis
    Genc, Halil
    Dogru, Teoman
    Tapan, Serkan
    Kara, Muammer
    Ercin, Cemal Nuri
    Aslan, Fatih
    Kantarcioglu, Murat
    Karslioglu, Yildirim
    Sertoglu, Erdim
    Erbil, Mehmet Kemal
    Bagci, Sait
    [J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2011, 46 (11) : 1355 - 1361