Heartburn, reflux and epigastric pain are frequently encountered symptoms in primary care medicine. Acid peptic diseases such as peptic ulcer and gastrointestinal reflux disease have a high prevalence, can have important impact on patient quality of life and represent a considerable health care cost. Proton pump inhibitors (PPIs) are the most potent pharmacological inhibitors of gastric acid secretion currently available and are the mainstay medical therapy for acid peptic diseases. This review summarizes current evidence on treatment of acid-peptic diseases with proton pump inhibitors and provides primary care clinicians with best practice guidelines for optimal use of these drugs.
机构:
Karolinska Inst, Canc Ctr Karolinska, Dep Oncol Pathol, Stockholm, Sweden
Ist Super Sanita, Unit Antitumor Drugs, Dept Therapeut Res & Med Evaluat, I-00161 Rome, ItalyKarolinska Inst, Canc Ctr Karolinska, Dep Oncol Pathol, Stockholm, Sweden
De Milito, Angelo
Marino, Maria Lucia
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机构:
Ist Super Sanita, Unit Antitumor Drugs, Dept Therapeut Res & Med Evaluat, I-00161 Rome, ItalyKarolinska Inst, Canc Ctr Karolinska, Dep Oncol Pathol, Stockholm, Sweden
Marino, Maria Lucia
Fais, Stefano
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Ist Super Sanita, Unit Antitumor Drugs, Dept Therapeut Res & Med Evaluat, I-00161 Rome, ItalyKarolinska Inst, Canc Ctr Karolinska, Dep Oncol Pathol, Stockholm, Sweden
机构:
Montefiore Med Ctr, Dept Med, Geriatr Med Fellowship Program, Geriatr Med, Wakefield Campus, Bronx, NY 10466 USA
Albert Einstein Coll Med, Bronx, NY 10467 USAMontefiore Med Ctr, Dept Med, Geriatr Med Fellowship Program, Geriatr Med, Wakefield Campus, Bronx, NY 10466 USA