Synthesis and antiviral activity of lycorine derivatives

被引：5

作者：

Yang, Ya-Jun ^{[1
]}

Liu, Jiang-Ning ^{[2
]}

Pan, Xian-Dao ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Act Subst Discovery & Drug Abil E, Beijing 100050, Peoples R China

[2] Chinese Acad Med Sci, Peking Union Med Coll, Inst Lab Anim Sci, Natl Hlth Commiss China NHC,Key Lab Human Dis Com, Beijing 100050, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2020年 / 22卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Lycorine; hand; foot; and mouth disease; enterovirus; 71; coxsackievirus A16; ENTEROVIRUS; MORTALITY; FOOT; HAND;

D O I：

10.1080/10286020.2020.1844674

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

There are no effective antiviral drugs to treat hand, foot, and mouth disease. In this study, a series of lycorine derivatives were synthesized and evaluated against enterovirus 71 and coxsackievirus A16 in vitro. Derivatives 7c-m with the phenoxyacyl group at the C-1 position showed higher efficacy and lower toxicity than lycorine. In addition, derivative 7e enhanced the survival rate to 40% in the mouse model of the lethal EV71 infection.

引用

页码：1188 / 1196

页数：9