Synthesis and antiviral activity of lycorine derivatives

被引：5

作者：

Yang, Ya-Jun ^{[1
]}

Liu, Jiang-Ning ^{[2
]}

Pan, Xian-Dao ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Act Subst Discovery & Drug Abil E, Beijing 100050, Peoples R China

[2] Chinese Acad Med Sci, Peking Union Med Coll, Inst Lab Anim Sci, Natl Hlth Commiss China NHC,Key Lab Human Dis Com, Beijing 100050, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2020年 / 22卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Lycorine; hand; foot; and mouth disease; enterovirus; 71; coxsackievirus A16; ENTEROVIRUS; MORTALITY; FOOT; HAND;

D O I：

10.1080/10286020.2020.1844674

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

There are no effective antiviral drugs to treat hand, foot, and mouth disease. In this study, a series of lycorine derivatives were synthesized and evaluated against enterovirus 71 and coxsackievirus A16 in vitro. Derivatives 7c-m with the phenoxyacyl group at the C-1 position showed higher efficacy and lower toxicity than lycorine. In addition, derivative 7e enhanced the survival rate to 40% in the mouse model of the lethal EV71 infection.

引用

页码：1188 / 1196

页数：9

共 21 条

[1] Design, Synthesis and Structure-Activity Relationship Optimization of Lycorine Derivatives for HCV Inhibition [J].

Chen, Duozhi ;

Cai, Jieyun ;

Cheng, Junjun ;

Jing, Chenxu ;

Yin, Junlin ;

Jiang, Jiandong ;

Peng, Zonggen ;

Hao, Xiaojiang .

SCIENTIFIC REPORTS, 2015, 5

[2] Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors [J].

Chen, Duozhi ;

Cai, Jieyun ;

Yin, Junlin ;

Jiang, Jiandong ;

Jing, Chenxu ;

Zhu, Yanping ;

Cheng, Junjun ;

Di, Yingtong ;

Zhang, Yu ;

Cao, Mingming ;

Li, Shunlin ;

Peng, Zonggen ;

Hao, Xiaojiang .

FUTURE MEDICINAL CHEMISTRY, 2015, 7 (05) :561-570

[3]

Chen LX, 2014, SPRBRIEF MOLEC SCI, P9, DOI 10.1007/978-3-662-43624-0_2

[4]

Esposito S., 2018, EUR J CLIN MICROBIOL, V37

[5] In search of a cytostatic agent derived from the alkaloid lycorine: Synthesis and growth inhibitory properties of lycorine derivatives [J].

Evdokimov, Nikolai M. ;

Lamoral-Theys, Delphine ;

Mathieu, Veronique ;

Andolfi, Anna ;

Frolova, Liliya V. ;

Pelly, Stephen C. ;

van Otterlo, Willem A. L. ;

Magedov, Igor V. ;

Kiss, Robert ;

Evidente, Antonio ;

Kornienko, Alexander .

BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (23) :7252-7261

[6] A Conserved Inhibitory Mechanism of a Lycorine Derivative against Enterovirus and Hepatitis C Virus [J].

Guo, Yu ;

Wang, Yaxin ;

Cao, Lin ;

Wang, Peng ;

Qing, Jie ;

Zheng, Qizhen ;

Shang, Luqing ;

Yin, Zheng ;

Sun, Yuna .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2016, 60 (02) :913-924

[7] Epidemiology of Recurrent Hand, Foot and Mouth Disease, China, 2008-2015 [J].

Huang, Jiao ;

Liao, Qiaohong ;

Ooi, Mong How ;

Cowling, Benjamin J. ;

Chang, Zhaorui ;

Wu, Peng ;

Liu, Fengfeng ;

Li, Yu ;

Luo, Li ;

Yu, Shuanbao ;

Yu, Hongjie ;

Wei, Sheng .

EMERGING INFECTIOUS DISEASES, 2018, 24 (03) :432-442

[8]

Liu J., 2011, VIROL J, V8

[9]

Liu X, 2012, ELSEV INSIGHT, P17, DOI 10.1016/B978-0-12-397010-7.00003-3

[10] Hand, Foot, and Mouth Disease in an Adult [J].

Murase, Chiaki ;

Akiyama, Masashi .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (14) :E20-E20

← 1 2 3 →