Molecular biology of gynecological cancer (Review)

被引：17
作者：
Sonoda, Kenzo [1 ]
机构：
[1] Kyushu Univ, Grad Sch Med Sci, Dept Obstet & Gynecol, Fukuoka, Fukuoka 8128582, Japan
来源：
ONCOLOGY LETTERS | 2016年 / 11卷 / 01期
基金：
日本学术振兴会;
关键词：
gynecological cancer; molecular biology; oncogenesis; angiogenesis; targeted therapy; SISO CELLS RCAS1; OVARIAN-CANCER; BRCA2; MUTATIONS; E-CADHERIN; ADENOMATOUS POLYPOSIS; PERSONALIZED MEDICINE; HUMAN-PAPILLOMAVIRUS; TUMOR HETEROGENEITY; FAMILY-HISTORY; SEROUS OVARIAN;
D O I：
10.3892/ol.2015.3862
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer is a pathological condition in which the balance between cell growth and death is disordered. Various molecules have been reported to be involved in the oncogenic process of invasion, metastasis and resistance to treatment. An exponential growth in the collection of genomic and proteomic data in the past 20 years has provided major advances in understanding the molecular mechanisms of human cancer, which has been applied to diagnostic and treatment strategies. Targeted therapies have been developed and adopted, particularly for advanced, refractory or recurrent cancers, depending on individual molecular profiles. The aim of the present review is to provide a report of the current literature regarding the molecular biology of gynecological cancers.
引用
收藏
页码：16 / 22
页数：7
相关论文
共 134 条
  • [1] American Cancer Society, 2015, GLOB CANC FACTS FIG, P34
  • [2] [Anonymous], 2015, The Condition of College Career Readiness 2015: Hispanic Students, P24
  • [3] Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history:: A combined analysis of 22 studies
    Antoniou, A
    Pharoah, PDP
    Narod, S
    Risch, HA
    Eyfjord, JE
    Hopper, JL
    Loman, N
    Olsson, H
    Johannsson, O
    Borg, Å
    Pasini, B
    Radice, P
    Manoukian, S
    Eccles, DM
    Tang, N
    Olah, E
    Anton-Culver, H
    Warner, E
    Lubinski, J
    Gronwald, J
    Gorski, B
    Tulinius, H
    Thorlacius, S
    Eerola, H
    Nevanlinna, H
    Syrjäkoski, K
    Kallioniemi, OP
    Thompson, D
    Evans, C
    Peto, J
    Lalloo, F
    Evans, DG
    Easton, DF
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 72 (05) : 1117 - 1130
  • [4] APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q
    Arnold, CN
    Goel, A
    Niediwiecki, D
    Dowell, JM
    Wasserman, L
    Compton, C
    Mayer, RJ
    Bertagnolli, MM
    Boland, CR
    [J]. CANCER BIOLOGY & THERAPY, 2004, 3 (10) : 960 - 964
  • [5] The angiogenic switch in carcinogenesis
    Baeriswyl, Vanessa
    Christofori, Gerhard
    [J]. SEMINARS IN CANCER BIOLOGY, 2009, 19 (05) : 329 - 337
  • [6] Carcinogenic mechanisms of endometrial cancer: Involvement of genetics and epigenetics
    Banno, Kouji
    Yanokura, Megumi
    Iida, Miho
    Masuda, Kenta
    Aoki, Daisuke
    [J]. JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2014, 40 (08) : 1957 - 1967
  • [7] Aberrant Epigenetic Landscape in Cancer: How Cellular Identity Goes Awry
    Berdasco, Maria
    Esteller, Manel
    [J]. DEVELOPMENTAL CELL, 2010, 19 (05) : 698 - 711
  • [8] Haplo-insufficiency: a driving force in cancer
    Berger, Alice H.
    Pandolfi, Pier Paolo
    [J]. JOURNAL OF PATHOLOGY, 2011, 223 (02) : 137 - 146
  • [9] Phosphorylation of tyrosine 992, 1068, and 1086 is required for conformational change of the human epidermal growth factor receptor C-terminal tail
    Bishayee, A
    Beguinot, L
    Bishayee, S
    [J]. MOLECULAR BIOLOGY OF THE CELL, 1999, 10 (03) : 525 - 536
  • [10] Brinckerhoff CE, 2000, CLIN CANCER RES, V6, P4823
12345678910