Light-scattering signals from nanoparticles in biochemical assay, pharmaceutical analysis and biological imaging

被引：77
作者：
Ling, Jian
Huang, Cheng Zhi [1 ]
Li, Yuan Fang
Zhang, Li
Chen, Li Qiang
Zhen, Shu Jun
机构：
[1] Southwest Univ, Coll Chem & Chem Engn, Chongqing 400715, Peoples R China
来源：
TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2009年 / 28卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Aggregation; Analyte; Biochemical assay; Biological imaging; Detection; Fluorescence; Light-scattering signal; Nanomaterial; Nanoparticle; Pharmaceutical analysis; PLASMON RESONANCE SPECTROSCOPY; HIGHLY FLUORESCENT ANALOGS; GOLD NANOPARTICLES; NANOGRAM LEVELS; SPECTRAL ASSAY; COLORIMETRIC DETECTION; QUANTITATIVE-DETERMINATION; SUBMICROSCOPIC PARTICLES; HOMOGENEOUS DETECTION; RAYLEIGH-SCATTERING;
D O I：
10.1016/j.trac.2009.01.003
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Light scattered from nanoparticles (NPs) can easily be observed by the naked eye. Light-scattering signals from nanomaterials have been applied extensively for analysis (e.g., in biochemical and pharmaceutical sciences). Metal NPs with defined components, size and shape can be used as fluorescent analogs for labeling biomolecules in biochemical analysis and biological imaging, due to the colors of the scattered light, if excited with a white-light source. Enhanced light-scattering signals from aggregates of NPs induced by analytes can be used for monitoring molecular interaction or quantitative detection of analytes. Due to the advantages of simplicity and sensitivity, light-scattering spectrometric methods based on nanomaterials have shown great promise. In this contribution, we review applications of light-scattering signals from NPs in biochemical assay, pharmaceutical analysis and biological imaging. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：447 / 453
页数：7
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