Human Retinal Pigment Epithelium Stem Cell (RPESC)

被引:26
|
作者
Saini, Janmeet S. [1 ,2 ]
Temple, Sally [1 ]
Stern, Jeffrey H. [1 ]
机构
[1] Regenerat Res Fdn, Neural Stem Cell Inst, One Discovery Dr, Rensselaer, NY 12144 USA
[2] SUNY Albany, Dept Biomed Sci, Albany, NY 12201 USA
来源
RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY | 2016年 / 854卷
关键词
Retina; Stem cells; Tissue specific stem cells; Retinal pigment epithelium (RPE); Retinal pigment epithelium stem cells (RPESC); Regeneration; Disease modeling; Epiretinal membrane; Transplantation; Endogenous repair; FIBROBLAST-GROWTH-FACTOR; VERTEBRATE EYE; REGENERATION; MONOLAYERS; SPECIFICATION; COMPONENTS;
D O I
10.1007/978-3-319-17121-0_74
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The retinal pigment epithelium (RPE) is a pigmented cellular monolayer that supports photoreceptor cells located in the overlying neural retina. The RPE is critical for vision and its dysfunction results in numerous pathologies, several with limited available disease-altering strategies. Regeneration of the retina from RPE is robust in lower vertebrates, but is not normally exhibited in mammals. We recently found that a subpopulation of human RPE cells can be stimulated in culture to generate multipotent self-renewing cells-the RPE stem cell (RPESC). RPESC can be expanded to generate RPE progeny that are a potential source for cell replacement therapy. Alternatively, RPESC can produce mesenchymal progeny which serve as a disease model of epiretinal membrane formation. Yet another potential application of RPESCs is activation within the eye to awaken dormant endogenous repair.
引用
收藏
页码:557 / 562
页数:6
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