Cross-presentation by human dendritic cell subsets

被引：39

作者：

Segura, Elodie ^{[1
,2
]}

Amigorena, Sebastian ^{[1
,2
]}

机构：

[1] INSERM, U932, F-75005 Paris, France

[2] Inst Curie, Sect Rech, F-75005 Paris, France

来源：

IMMUNOLOGY LETTERS | 2014年 / 158卷 / 1-2期

基金：

欧洲研究理事会;

关键词：

Dendritic cells; Cross-presentation; CD8+T cells; Vaccination; HUMAN LANGERHANS CELLS; CD8(+) T-CELLS; HUMAN BLOOD; STEADY-STATE; ANTIGEN CROSSPRESENTATION; VIRAL-ANTIGENS; ACTIVATION; EXPRESSION; RESIDENT; SPLEEN;

D O I：

10.1016/j.imlet.2013.12.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) are a heterogeneous population of professional antigen-presenting cells. Several murine DC subsets differ in their phenotype and functional properties, in particular in their ability to cross-present antigens (i.e. to present exogenous antigens on their MHC class I molecules). In humans, distinct DC subpopulations have also been identified but whether some human DC subsets are also specialized at cross-presentation remains debated. Here we review the DC subsets that have been identified in humans and we discuss recent work that addresses their ability to cross-present antigens and their efficiency for CD8(+) T cells activation. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：73 / 78

页数：6

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