Cholesterol and cognitive performance among community volunteers from the Czech Republic

被引:16
作者
Chanti-Ketterl, Marianne [1 ]
Andel, Ross [1 ]
Lerch, Ondrej [2 ,3 ]
Laczo, Jan [2 ,3 ]
Hort, Jakub [4 ]
机构
[1] Univ S Florida, Sch Aging Studies, Tampa, FL 33612 USA
[2] Charles Univ Prague, Memory Clin, Dept Neurol, Fac Med 2, CR-11636 Prague 1, Czech Republic
[3] Motol Univ Hosp, Prague, Czech Republic
[4] St Annes Univ Hosp, Int Clin Res Ctr, Brno, Czech Republic
关键词
cholesterol; lipoproteins; cognition; older adults; HDL-C; HIGH-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN-E; SERUM-CHOLESTEROL; NORMATIVE DATA; PLASMA-LIPIDS; RISK-FACTOR; MEMORY; DECLINE; ASSOCIATION; NORMS;
D O I
10.1017/S1041610215000320
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Background: Research shows that lipid levels may be associated with cognitive function, particularly among women. We aimed to examine total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), high-density lipoprotein (HDL), andHDL/LDL ratio in relation to cognitive performance, measured with six well-established cognitive domains and a composite cognitive score (CCS). Methods: In this cross-sectional study, biomarkers and neuropsychological assessment were available for 141 adults with MMSE scores >= 24 (mean age = 69 years, 47% female, mean education = 14.4 years) attending a neuropsychological evaluation. Ordinary least squares regressions were adjusted for age, gender, education, and depressive symptoms in Model 1 and also for apolipoprotein E4 (APOE4) status in Model 2. Results: High-density lipoprotein cholesterol (HDL-C) was associated with better CCS (beta = 0.24; p = 0.014). This association was significant among women (beta = 0.30; p = 0.026) and not among men (beta = 0.20; p = 0.124). HDL-C was also related to attention/working memory (beta = 0.24; p = 0.021), again only among women (beta = 0.37; p = 0.012) and not men (beta = 0.15; p = 0.271). Adjusting for APOE4 yielded significance for high HDL-C and CCS (beta = 0.24; p = 0.022). Conclusions: HDL-C was the main lipoprotein affecting cognitive function, with results somewhat more pronounced among women. Research should investigate the possibility of finding ways to boost HDL-C levels to potentially promote cognitive function.
引用
收藏
页码:2087 / 2095
页数:9
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