Regio- and Chemoselective Formation of Spiroindolinone-Isoindolinone by a Palladium-Catalyzed Buchwald-Hartwig Addition-Elimination Sequence

被引：28

作者：

Butani, Himanshu H. ^{[1
,2
]}

Vachhani, Dipak D. ^{[1
]}

Bhoya, Umed C. ^{[2
]}

Shah, Anamik K. ^{[2
]}

Van der Eycken, Erik V. ^{[1
]}

机构：

[1] Univ Leuven KU Leuven, Dept Chem, Lab Organ & Microwave Assisted Chem LOMAC, B-3001 Leuven, Belgium

[2] Saurashtra Univ, Dept Chem, Rajkot 360005, Gujarat, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 30期

关键词：

Post-Ugi cascade cyclizations; Multicomponent reactions; Heterocycles; Palladium; Spiroindolinones; MULTICOMPONENT REACTIONS; HIGHLY EFFICIENT; ENANTIOSELECTIVE CONSTRUCTION; 3+2 ANNULATION; UGI; OXINDOLES; SPIROOXINDOLES; DESIGN; ISATIN; HETEROCYCLES;

D O I：

10.1002/ejoc.201402909

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The usual way to synthesize spiroindolinones is the application of isatin derivatives. Here, we report the first Pd-catalyzed Buchwald-Hartwig addition-elimination strategy for the formation of the spiroindolinone-isoindolinone architecture. The application of the Ugi-4-component reaction (Ugi-4CR) allows the facile introduction of diversity and increases the practicality of this protocol.

引用

页码：6634 / 6638

页数：5

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