Immune Regulation of Antibody Access to Neuronal Tissues

被引：57

作者：

Iwasaki, Akiko ^{[1
]}

机构：

[1] Yale Univ Sch Med, Howard Hughes Med Inst, Dept Immunobiol, New Haven, CT 06520 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2017年 / 23卷 / 03期

基金：

美国国家卫生研究院;

关键词：

BLOOD-BRAIN-BARRIER; TIGHT JUNCTION PROTEINS; CENTRAL-NERVOUS-SYSTEM; ZIKA VIRUS; T-CELLS; AMYLOID-BETA; ENDOTHELIAL-CELLS; HERPES-SIMPLEX; NEURAL PROGENITORS; ALZHEIMERS-DISEASE;

D O I：

10.1016/j.molmed.2017.01.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review highlights recent advances in how the innate and adaptive immune systems control the blood-brain barrier (BBB) and the blood-nerve barrier (BNB). Interferons and TAM receptors play key roles in innate immune control of the BBB. Cells of the adaptive immune system, particularly CD4(+) T cells, take distinct routes to enter neural tissues and mediate immune surveillance. Furthermore, T cell-mediated opening of the BBB and the BNB is crucial to allow antibody access and thereby block the replication of neurotropic viruses. Such novel insights gained from basic research provide key foundations for future design of therapeutic strategies-enabling antibody access to the brain may be key to cancer immunotherapy and to the use of vaccines against neurodegenerative conditions such as Alzheimer's disease.

引用

页码：227 / 245

页数：19

共 102 条

[1] A fresh perspective from immunologists and vaccine researchers: Active vaccination strategies to prevent and reverse Alzheimer's disease [J].

Agadjanyan, Michael G. ;

Petrovsky, Nikolai ;

Ghochikyan, Anahit .

ALZHEIMERS & DEMENTIA, 2015, 11 (10) :1246-1259

[2] The pathogenesis of spinal cord involvement in dengue virus infection [J].

An, J ;

Zhou, DS ;

Kawasaki, K ;

Yasui, K .

VIRCHOWS ARCHIV, 2003, 442 (05) :472-481

[3]

Annie Y., 2015, ELIFE, V4, P03733

[4] Regional Neural Activation Defines a Gateway for Autoreactive T Cells to Cross the Blood-Brain Barrier [J].

Arima, Yasunobu ;

Harada, Masaya ;

Kamimura, Daisuke ;

Park, Jin-Haeng ;

Kawano, Fuminori ;

Yull, Fiona E. ;

Kawamoto, Tadafumi ;

Iwakura, Yoichiro ;

Betz, Ulrich A. K. ;

Marquez, Gabriel ;

Blackwell, Timothy S. ;

Ohira, Yoshinobu ;

Hirano, Toshio ;

Murakami, Masaaki .

CELL, 2012, 148 (03) :447-457

[5]

Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene), NAT GENET, V41, P824

[6] THE PATHOGENESIS OF ADOPTIVE MURINE AUTOIMMUNE DIABETES REQUIRES AN INTERACTION BETWEEN ALPHA-4-INTEGRINS AND VASCULAR CELL-ADHESION MOLECULE-1 [J].

BARON, JL ;

REICH, EP ;

VISINTIN, I ;

JANEWAY, CA .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (04) :1700-1708

[7] SURFACE EXPRESSION OF ALPHA-4 INTEGRIN BY CD4 T-CELLS IS REQUIRED FOR THEIR ENTRY INTO BRAIN PARENCHYMA [J].

BARON, JL ;

MADRI, JA ;

RUDDLE, NH ;

HASHIM, G ;

JANEWAY, CA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (01) :57-68

[8] Mfsd2a is critical for the formation and function of the blood-brain barrier [J].

Ben-Zvi, Ayal ;

Lacoste, Baptiste ;

Kur, Esther ;

Andreone, Benjamin J. ;

Mayshar, Yoav ;

Yan, Han ;

Gu, Chenghua .

NATURE, 2014, 509 (7501) :507-+

[9] Amyloid-β and Tau The Trigger and Bullet in Alzheimer Disease Pathogenesis [J].

Bloom, George S. .

JAMA NEUROLOGY, 2014, 71 (04) :505-508

[10] Risk of Natalizumab-Associated Progressive Multifocal Leukoencephalopathy [J].

Bloomgren, Gary ;

Richman, Sandra ;

Hotermans, Christophe ;

Subramanyam, Meena ;

Goelz, Susan ;

Natarajan, Amy ;

Lee, Sophia ;

Plavina, Tatiana ;

Scanlon, James V. ;

Sandrock, Alfred ;

Bozic, Carmen .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (20) :1870-1880

← 1 2 3 4 5 6 7 8 9 10 →